MEDICATION PRECAUTIONS for PSP, CBD and MSA
DO NOT ABRUPTLY INCREASE OR REDUCE LEVODOPA OR AMANTADINE. TO AVOID:
• Pimavanserin, quetiapine and clozapine: can be used in brief, emergency situations but can cause aggravation of slowness and stiffness
• Benzodiazepines( clonazepam, temazepam) and benzodiazepine receptor agonists( zolpidem, eszopiclone): can increase risk of falls, but can be used if person is chairbound and hypotension is not a risk
TO USE WITH CAUTION:
• Haloperidol, olanzapine, aripiprazole and risperidone: can dangerously aggravate stiffness and slowness and cause severe sedation
• Amitriptyline, benztropine, trihexyphenidyl, oxybutynin, tolterodine, fesoterodine, paroxetine and most tricyclic antidepressants: can worsen mobility
• Diphenhydramine, an antihistamine with anticholinergic effects: can worsen mobility
• Memantine: can cause nausea, dizziness and sedation
• Metoclopramide and prochlorperazine: for nausea / vomiting, instead use ondansetron, trimethobenzamide or granisetron
FOR MSA:
• Dopamine agonists: can cause dystonia
• Alpha-blockers for bladder dysfunction and beta blockers for anything: can cause sudden hypotension
CurePSP Prepare to Care 16