1.1 List of Tables 5 1.2 List of Figures 6
2 Introduction 7 2.1 Overview of Private Equity and Venture Capital 7 2.1.1 Private Equity and Venture Capital : Similarities and Differences 7 2.1.2 The Importance of Adequate Fundraising for PE and VC firms 8 2.2 The Significance of Private Equity and Venture Capital in the Healthcare Industry 8 2.2.1 The Venture-Backed Healthcare Innovation Model 9 2.2.2 Critical Factors to Consider when Selecting a Venture Capital Firm 11 2.2.3 What Are the Types of Private Equity Firms Operating in the Healthcare Industry ? 12
3 Global Trends in Private Equity and Venture Capital Investments in the Healthcare Industry 13 3.1 Is R & D Productivity in Healthcare Still Declining ? 13 3.2 What is Causing the Increase in the Cost of Bringing Medical Interventions to Market ? 13 3.3 Global Healthcare Private Equity Deal Trends : Volume and Value , 2006-2015 14 3.4 Regional Healthcare Private Equity Deal Trends : Volume and Value , 2006-2015 15 3.5 Which Therapy Areas Are Receiving Noteworthy Private Equity Investment ? 17 3.6 Top 10 Healthcare Private Equity Deals , 2015 17 3.7 Top 10 Healthcare Venture Capital Deals , 2015 19 3.8 Are New Companies in the Healthcare Industry Living in a Post-VC Era ? 20 3.9 What are the Risks if Investments in the Healthcare Industry Decrease Significantly ? 20 3.10 New Funding and Investment Models Emerging in the Healthcare Industry 21 3.10.1 The Role of Crowdfunding in Early-Stage Healthcare in the Post-VC Era 21
4 US Private Equity and Venture Capital Industry Dynamics 23 4.1 Immediate Aftermath of the 2008 Global Financial Crisis on the Value of Capital Commitments to Private Funds in the US 23 4.2 Venture Capital Fundraising Trends in the US : Volume and Value of Funds , 2006-2015 23 4.3 US Venture Capital Investment Trends 24 4.4 Is Biotechnology Still Playing Second Fiddle to the Software Sector ? 25 4.5 Trends in Seed Stage VC Financing in the US by Volume and Value , 2015 27 4.6 US Venture-Backed Exits , Volume and Value , 2006-2015 28 4.7 US Venture-Backed Healthcare Acquisitions 2006-2015 30
5 Equity Offerings in the Healthcare Sector , Value and Volume , 2006-2015 31 5.1 US Venture-Backed Initial Public Offerings in Healthcare , 2006-2015 31 5.2 Company Profiles and Initial Public Offer Details 33 5.2.1 Axovant Sciences ( Stock Symbol : AXON ) 33 5.2.2 NantKwest ( Stock Symbol : NK ) 33 5.2.3 Adaptimmune Therapeutics ( Stock Symbol : ADAP ) 34 5.2.4 Spark Therapeutics ( Stock Symbol : ONCE ) 36 5.2.5 Aimmune Therapeutics ( Stock Symbol : AIMT ) 37 5.2.6 Blueprint Medicines ( Stock Symbol : BPMC ) 37 5.2.7 RegenxBio ( Stock Symbol : RGNX ) 38 5.2.8 ProNAi Therapeutics ( Stock Symbol : DNAI ) 39 5.2.9 Seres Therapeutics ( Stock Symbol : MCRB ) 40 5.2.10 Global Blood Therapeutics ( Stock Symbol : GBT ) 41
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