Pharmaceutical Industry Reports Gene Synthesis Market | Page 2

REPORT DESCRIPTION
Gene Synthesis Market – Overview
Gene synthesis is chemically in vitro synthesis of double-stranded DNA molecules. It is a technology used in
biotechnology and plays an important role in the field of synthetic biology. The technology has become a
significant tool in various fields of recombinant DNA technology including gene therapy, vaccine
development, molecular engineering, and heterologous gene expression. It can help in designing novel
enzymes for cancer treatment. Also, it can be used in diagnosis of viral genomes for vaccine development in
real-time. Gene synthesis can develop mutated, recombinant, or entirely novel DNA sequences without any
template DNA strand. Moreover, it can also synthesize, oligos and RNA containing modified bases or
chimeric DNA-RNA backbones along with DNA sequences.
Custom gene synthesis derives from oligonucleotide synthesis technology and is the gold standard method
for synthesis of PCR primers. Gene synthesis builds on this platform and uses exclusive technologies to join
the oligos to synthesize full gene sequence. The price for custom gene synthesis was around US$ 0.69/base,
earlier. Gene synthesis is a useful codon optimization tool to circumvent codon bias problems during
heterologous protein expression. Protein expression can be improved considerably by designing DNA
sequences with only codons preferred by the intended expression host.
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