urinary tract infection, upper respiratory tract infection, nasopharyngitis,
influenza, sinusitis, and bronchitis Injury, poisoning and procedural complications: fall Metabolism and nutrition disorders: anorexia Musculoskeletal and
connective tissue disorders: back pain, arthralgia, pain in extremity, muscle
spasms, musculoskeletal pain, joint swelling, neck pain, and myalgia Nervous
system disorders: hypoesthesia, tremor, migraine, and paresthesia Psychiatric
disorders: insomnia, anxiety, and depression Respiratory, thoracic and mediastinal disorders: dyspnea, pharyngolaryngeal pain, and cough Skin and
subcutaneous tissue disorders: pruritus, hyperhidrosis, rash, and generalized
pruritus Vascular disorders: hypertension Other less common adverse reactions, including those known to occur with opioid treatment, that were seen
in < 1% of the patients in the BUTRANS trials include the following in
alphabetical order: Abdominal distention, abdominal pain, accidental injury,
affect lability, agitation, alanine aminotransferase increased, angina pectoris,
angioedema, apathy, application site dermatitis, asthma aggravated, bradycardia, chills, confusional state, contact dermatitis, coordinatio