DRUG INTERACTIONS
Alcohol
Concomitant use of alcohol with OPANA ER can result in an increase of oxymorphone
plasma levels and potentially fatal overdose of oxymorphone. Instruct patients not
to consume alcoholic beverages or use prescription or non-prescription products
containing alcohol while on OPANA ER therapy (see Clinical Pharmacology).
CNS Depressants
Concurrent use of OPANA ER and other CNS depressants including sedatives,
hypnotics, tranquilizers, general anesthetics, phenothiazines, other opioids, and
alcohol can increase the risk of respiratory depression, hypotension, profound
sedation, or coma. Monitor patients receiving CNS depressants and OPANA ER for
signs of respiratory depression and hypotens