3. Mental
Deterioration
Neuroinflammation causes tissue destruction and cellular loss
that may result in losses of memory, reading ability, attention span, and
logical thinking.15,16 Dementia can occur, resulting in the need for
domiciliary care. There appears to be considerable loss of
brain tissue in severe cases.17-20
e
e
e
terminology clarification
C NTRALiZ D VS C NTRAL PAiN:
Centralized has recently emerged as the consensus term meaning that pain initially started in the periphery and migrated into the
CNS. It may also begin de novo in the CNS.21 The latter type of
pain disorders include fibromyalgia, irritable bowel syndrome, interstitial cystitis, vulvodynia, prostatitis, and temporal mandibular joint
disorder.3,4,19 At this time, central pain remains the t \