RESEARCH AND CLINICAL TRIALS
Top Enrolling Studies
The following studies were known as top enrolling :
ALLOMAP STUDY Observe short and long-term clinical outcomes in heart transplant recipients who receive regular AlloMap testing as part of allograft rejection surveillance , sponsored by CareDx . Number one ranked in the world .
ALNYLAM Expanded-access protocol of Patisiran for patients with hereditary transthyretinmediated amyloidosis ( hATTR amyloidosis ) with polyneuropathy . Top-ranked nationally .
COAPT CAS This study is an extension of the COAPT Randomized Control Trial ( RCT ) under the same IDE as COAPT RCT . COAPT CAS will collect additional safety and effectiveness data to support the Premarket Approval ( PMA ) application of the labeling claims for the treatment of moderate-to-severe or severe functional mitral regurgitation ( FMR ) in symptomatic heart failure subjects who are treated per standard of care and who have been determined by the site ’ s local heart team as not appropriate for mitral valve surgery . Top-ranked nationally .
DREAM STEM CELL STUDY Assess the safety of allogeneic mesenchymal precursor cells ( rexlemestrocel-L ) in patients with chronic heart failure due to left ventricular systolic dysfunction of either ischemic or nonischemic etiology , sponsored by Mesoblast , Inc . Top-ranked nationally .
EVOLVE - SHORT DAPT STUDY A trial of early discontinuation of antiplatelets for patients treated with the Boston Scientific SYNERGY stent . Top-ranked worldwide .
GALACTIC STUDY Obtain an assessment of the efficacy and safety of Omecamtiv Mecarbil on mortality and morbidity in subjects with chronic heart failure with reduced ejection fraction , sponsored by Amgen . Top-ranked nationally .
MOMENTUM 3 CAP STUDY Evaluate the safety and effectiveness of the HeartMate III LVAD by demonstrating noninferiority to the HeartMate II LVAD when used for the treatment of advanced , refractory , left ventricular heart failure , sponsored by St . Jude Medical . Ranked in top six enrollment sites nationally .
PRESERVED-HF STUDY Observe the effects of Dapagliflozin on biomarkers , symptoms and functional status in patients with Type 2 diabetes or pre-diabetes , and preserved ejection fraction heart failure , sponsored by Saint Luke ’ s Health System . Top-ranked nationally .
SOPRANO Assess the safety and efficacy of Macitentan in patients with pulmonary hypertension after left ventricular assist device ( LVAD ) implantation . Top-ranked nationally .
SPYRAL HTN-OFF MED STUDY Obtain an assessment of the efficacy and safety of renal denervaton in the absence of antihypertensive medications , sponsored by Medtronic Vascular . Top-ranked nationally .
SPYRAL HTN — ON MED STUDY Obtain an assessment of the efficacy and safety of renal denervation in the presence of three standard antihypertensive medications , sponsored by Medtronic Vascular . Top-ranked nationally .
RESEARCH AND CLINICAL TRIALS – COMPLETE LISTING
Typically , at any given point in time , Baylor Scott & White Heart and Vascular Institute and Soltero Cardiovascular Research have more than 25 clinical trials open . For a comprehensive listing of open studies , please refer to
BaylorHeartHospital . com / ClinicalTrials .
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