While hundreds of studies and trials were conducted at Baylor Hamilton Heart and Vascular Hospital in fiscal year 2016 , Peter A . McCullough , MD , MPH , FACC , FACP , FAHA , FCCP , FNKF , FNLA , FCRSA , chief of cardiovascular research and education at the Baylor Heart and Vascular Institute for fiscal year 2016 , points to five projects initiated as prominent for Baylor Heart and Vascular Institute ’ s work :
1 . Clinical outcomes and metabolomics and damage associated molecular patterns of AKI in patients undergoing PCI via the radial versus femoral artery approach :
This study demonstrated in thousands of Baylor patients , that heart catheterization through the radial artery was associated with lower complication rates and reduced mortality . The ongoing laboratory portion of the study is prospectively evaluating candidate urine DAMPS and novel urine markers of CI-AKI as well as store research samples of urine for future genetic , genomic , proteomic , and metabolomics research in heart and kidney disease . Primary Investigator : Jeffrey M . Schussler , MD
2 . EXTEND-CRS :
A trial to examine the effects of a glucagon-like peptide agonist versus placebo on cardiac fibrosis as measured by MRI and echo imaging , as well as its effects on patients ’ Myocardial Injury Summary Score ( MISS ) and Kidney Injury Summary Score ( KISS ). The primary inclusion criteria are presence of Type II diabetes mellitus as well as mildly impaired renal function . The study is actively recruiting patients and has had the first few patients complete nine months of treatment with final cardiac MRI and ultrasound tests completed . Primary Investigator : Peter A . McCullough , MD , MPH
3 . ACHD-PRO :
This study of patients with heart defects from birth aims to evaluate the internal and test-retest reliability , assess the validity , and define the responsiveness and interpretability of this new ACHD PRO ( Adult Congenital Heart Disease Patient-Reported Outcome ) tool by exploiting clinical changes in patients ’ health status over time . Englishspeaking patients older than 17 years of age with a repaired , treated , or unrepaired CHD qualify for the study . Primary Investigator : Ari Cedars , MD
4 . Baylor Hypertrophic Cardiomyopathy Program Development Project :
Hypertrophic cardiomyopathy or abnormal thickness of the heart muscle is the leading cause of death in young athletes . Baylor is testing the most advanced genetic tests and cardiac imaging to detect the process earlier and understand why the heart muscle thickens in some but not in others . Time-resolved , 3D phase contrast magnetic resonance imaging ( MRI ) ( 4D Flow ) and Advanced Strain Rate Echocardiography in Patients with Hypertrophic Cardiomyopathy . Hypertrophic cardiomyopathy creates a characteristic blood flow pattern within heart chambers resulting in thickening of ventricular septum and causes a disarray of cardiac muscle fibers using cardiac MRI and echocardiogram with strain rate imaging . Study participants : patients older than 17 years of age with a positive genetic testing for hypertrophic cardiomyopathy , eGFR ≥ 50 ml / min / 1.73m2 , and capability to undergo MRI qualify for the study . Primary Investigator : Peter A . McCullough , MD , MPH
5 . PROMIS :
This government funded study organized by the Patient Centered Outcomes Research Institute will attempt to develop and evaluate a health assessment to phenotype heart failure patients . Newly diagnosed heart failure patients will complete a questionnaire followed by an optional phone survey . The primary inclusion criteria are presence of heart failure and absence of dementia . Primary Investigator : Peter A . McCullough , MD , MPH
OUTCOMES 2016
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