ORTHOPEDICS THIS WEEK VOLUME 14 , ISSUE 23 | JULY 17 , 2018 23 depression and various other mood disorders .”
“ Depression in these patients is also associated with more pain and increased functional disability . Previous studies suggest that when depressed arthritis patients undergo total hip or knee arthroplasty , they continue to experience worse functional outcomes , more surgical complications and more hospital readmissions .”
“ Therefore , there is growing interest in identifying strategies to effectively manage perioperative depression in an effort to improve functional and clinical outcomes in patients undergoing arthroplasty .”
“ We confirmed the findings of previous studies regarding an excess risk of revisions among depressed arthroplasty patients . In addition , we examined antidepressant treatment and showed that patients who received Selective Serotonin Reuptake Inhibitors ( SSRIs ) had a reduced risk of revisions .”
“ It is important to screen for depression in patients scheduled for arthroplasty surgery as it is an important risk factor for a variety of adverse surgical outcomes . In terms of effectiveness of SSRI in reducing the risk of revisions , our findings are preliminary and need to be replicated in future studies .”
“ This is an observational study and we cannot attribute causality . Future studies with longitudinal SSRI exposure data are warranted to replicate our observations and investigate the potential causative mechanisms for the protective benefit of SSRI in regard to risk of revision in arthroplasty .”
“ A diagnosis of depression is associated with a doubling of the risk of infections and the risk of revision arthroplasty . Despite this strong association , depression and psychiatric comorbidities and antidepressant use are rarely considered during the perioperative evaluation of arthroplasty candidates . It is important to recognize and manage psychiatric comorbidities in patients undergoing arthroplasty .” — EH
Making Cell-Based Cartilage Production Scalable
Due to its scientific relevance an article about stem cell produced cartilage by the International Stemcell Corporation ( ISCO ) has been featured on the cover of the May 2018 issue of the Journal of Tissue Engineering and Regenerative Medicine , a prestigious peer-reviewed scientific journal .
The article is titled “ Supplementation of Specific Carbohydrates Results in Enhanced Deposition of Chondrogenic-Specific Matrix during Mesenchymal Stem Cell Differentiation .”
The article discusses ISCO ’ s system developed that produces functional human cartilage tissue derived from the patient ’ s own skin or fat tissue which is scalable . The company claims that this process has the capacity to provide greater stability than other tissue that is currently available for the treatment of osteoarthritis .
ISCO scientists claim to have generated a healthy cartilage-specific matrix from human mesenchymal stem cells that had significantly higher viability and cartilage specific properties , including : proteoglycan , aggrecan , hyaluronic acid , and collagen II deposition and glycosaminoglycan production . This new cartilage-specific matrix was built in 3D format and is said to be ready for further therapeutic development .
“ While the treatment of Parkinson ’ s disease has always been at the forefront of our research efforts , we are also pursuing various other therapeutic indications . In one of those other areas , our R & D Team has significantly improved the process by which we can use the patient ’ s own mesenchymal stem cells to potentially treat osteoarthritis ,” said Russell Kern , Ph . D ., ISCO ’ s executive vice president and chief scientific officer . “ We are also thrilled to announce that this research gives us a basis to launch a program to develop supplements designed to potentially reduce joint pain and improve overall mobility ,” he added . — BY
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