NTU Undergraduates' research April 2014 - Biosciences | Seite 65

Wound healing of renal tubular epithelial cells (NRK52) following oxidative
stress and glucose induced damage: Role of transforming growth factor- β.
Artemis Christodoulou N0334414

Key words : TGF-β, wound healing, oxidative stress, glucose induction

Abstract:
Wound healing is a complex physiological response that requires the collaboration of many proteins
and growth factors. One of the most important proteins in normal wound resolution is transforming
growth factor-β (TGF-β), which orchestrates an array of physiological responses such as cell
differentiation and migration. The current study represents the investigation of TGF-β activity in
several cellular damage models, such as the use of hydrogen peroxide (H2O2) to induce oxidative
stress and increasing glucose concentrations. Furthermore, the investigation of the relationship,
between tissue transglutaminase 2 (TG2) and TGF-β, in response to wound repair is observed.