NTU Undergraduates' research April 2014 - Biosciences | Page 22

Inducing Apoptosis in Leukaemia Cells
Finbar T.K. Roberts
Nottingham Trent University – School of Science and Technology
Clifton, Nottingham, Nottinghamshire, United Kingdom
[e-mail]
N0367411

Abstract
Chronic myeloid leukaemia (CML) is a haematological neoplasm, which predominantly involves the uncontrolled
growth of aberrant myeloid stem cells; contributing to roughly 10% of new leukaemia cases each year. Commonly
associated with the chromosomal translocation of the Philadelphia chromosome, this uncommon cancer mainly affects
persons between the ages of 40-60. Prior to the development of tyrosine kinase inhibitors such as Imatinib in 2001,
the prognosis for newly diagnosed patients with the