NTU Undergraduates' research April 2014 - Biosciences | Seite 138

Exploration of repetitive sequence in bacterial genome
WONG SHUK MEI,Nottingham Trent University,UK
Repetitive DNA sequence are distributed in some of the most diverse genomic loci in
bacterial populations. They consist of short or long stretches of repeated nucleotide
sequence motifs that are repeated in tandem and vary in repeat copy number. Repeat copy
number variation at these loci may cause mutations resulting in the gain or loss of some
number of repeat units , such as affect the actual amino acid sequence of proteins.Finally
biological functions may alter. Bacterial pathogens exploit localized hypermutation and
generate phenotypic variation.(Marjan W. van der Woude and Andreas J.
Bäumler ,2004)Variation in the copy number for expression of a gene encoding a protein
involved in the synthesis of surface surface protein,the adhesion molecules,and encoding
genes about several iron binding protein genes that appear the variation .Many bacteria
use this random strategy to adapt their genetic repertoire in response to selective
environmental pressure. .( Paul B.Rainey, Moxon et al,1994)Therefore,this variation has
been noted as an important prerequisite for bacterial pathogenesis and evolutionary
fitness. (F.J. Bruijn, James R. Lupski, George M. Weinstock,1998).In th