NTU Undergraduates' research April 2014 - Biosciences | Page 119

Peggy Cho Kiu Lo N0363492

Title:
In vitro simulation of fibrosis in renal proximal tubular epithelial cells
(NRK-52E): The effect of elevated glucose on transforming growth
factor beta (TGF-β) activation and expression
Abstract. Elevated glucose concentration can lead to increase expression
of transforming growth factor-β (TGF-β), its signaling pathways can also
contribute to the result of fibrosis. It is essential to understand the
mechanism of different modulators that are involved in these pathways
and how they potentially control TGF-β expression in fibrosis, which may
involve as a therapeutic approach. This research was focused on the
effect of glucose and several other factors that often cause the rise of
TGF-β, including cyclosporine A, tissue transglutaminase and TG2
inhibitor R283; how these may interlink in relation to induce fibrosis.