Netupitant-Palonosetron FDC Market Figures and Analytical Insights, 2 Netupitant Healthcare | Page 4

Netupitant-Palonosetron FDC Market Opportunities, Demand and
Forecasts, 2017 - 2027
Netupitant-Palonosetron is the first approved fixed dose combination drug for the prevention of
chemotherapy induced nausea and vomiting. Cancer is a leading cause of death worldwide, accounting
nearly 1.4 million new cases in 2012. The most common type of cancer is lung cancer accounting about
1.59 million deaths, globally. Other prominent cancers are liver cancer, breast cancer, stomach cancer,
esophageal and stomach cancer. In 2012, nearly 8.2 million deaths occurred from aforementioned
indication, globally. Cancer can be treated by surgery, chemotherapy, radiation therapy, hormone
therapy, targeted therapy, precision medicine and stem cell transplantation. The most common
treatment for cancer is chemotherapy; it uses drugs to kill cancer cells that cause pain and other
problems. Chemotherapy given before surgery and radiation therapy to make the tumor cell smaller is
known as neo-adjuvant chemotherapy and chemotherapy given after treatment with surgery or radiation
therapy is known as adjuvant chemotherapy.
Chemotherapy, not only kills the cancer cells but also attacks healthy cells that leads to side effects such
as fatigue, hair loss, nausea, and vomiting. Chemotherapy-Induced Nausea and Vomiting (CINV) is one of
the most serious side effects that is taken into account. Chemotherapy-induced nausea and vomiting are
classified as acute, that occurs within 24 hours of the treatment; anticipatory, that is triggered due to
some exposed stimuli; other are refractory; delayed and breakthrough. Incidence, timing, and intensity of
chemotherapy-induced nausea and vomiting vary on chemotherapeutic agents and patient factors. CINV
occurs in about 80% of patients and has a severe impact on patient’s life.
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