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A recent study by von Hurst demonstrates that“ vitamin D-deficient South Asian women with evidence of insulin resistance had improved insulin sensitivity after 6 months following high-dose vitamin D supplementation, which was sufficient to raise vitamin D status from low to more optimal levels.” But there could be a‘ selection bias’,“ the apparent favorable effects found in this vitamin D intervention study on fasting insulin may be due to the researchers’ selection of insulin-resistant study subjects who had low initial vitamin D status(< 50 nmol / L) and received a relatively high daily dose of vitamin D, sufficient to increase their vitamin D status to near optimal levels.”
Some reseachers reported that Type 1 diabetes is found at a lower rate in places closer to the equator due to higher ultraviolet radiation-induced vitamin D synthesis in the skin.
In another research, scientists did not find a“ significant correlation between serum 25( OH) D levels and HbA1c or duration of diabetes.” Similarly, Janner had reported that“ there was no relationship between HbA1c levels and vitamin D status in T1D children and adolescents.” The daily insulin requirements of the subjects also did not change with their vitamin D status.
Maternal intake of vitamin D during pregnancy Pregnancy presents an additional risk for vitamin D deficiency due to increased maternal and fetal demands.
A study conducted by Jeanine Senti, Doria K. Thiele, and Cindy Miller Anderso signal that vitamin D supplementation during pregnancy would lower a patient’ s risk of developing gestational diabetes. This
3 Barbara J. Boucher.” p. 69
4 Christy S Maxwell and Richard J Wood, p. 294
5 E. Hyppo¨ nen.” Vitamin D and increasing incidence of type 1 diabetes— evidence for an association?” in Diabetes, Obesity and Metabolism 12: 2010, p. 738
6 Ajda Mutlu at all.” Vitamin D deficiency in Children and Adolescents with Type 1 Diabetes” in J Clin Res Pediatr En docrinol 2011; 3( 4): 182