MU Department of Medicine 2011-2013 Annual Report Feb. 2014

2011-2013 cardiovascular medicine cont. Department of Medicine 69 syndrome: use of a rodent model to examine mechanisms. Cardiorenal Med 1(1):23-30, 2011. Sun H, Xu Y, Sitkiewicz I, MA Y, Wang X, Yestrepsky BD, Huang Y, Lapadatescu MC, Larsen MJ, Larsen SD, Musser JM, Ginsburg Whaley-Connell AT, Habibi J, Nistala R, Demarco VG, Pulakat D. Inhibitor of streptokinase gene expression improves survival L, Hayden MR, Joginpally T, Ferrario CM, Parrish AR, Sowers JR. after group A streptococcus infection in mice. Proc Natl Acad Sci Mineralocorticoid receptor-dependent proximal tubule injury U S A. 2012 109:3469-3474. PMID: 22331877 is mediated by a redox- sensitive mTOR/S6K1 pathway. Am J Nephrol 35(1):90-100, 2012. Tricoci P, Huang Z, Held C, Moliterno DJ, Armstrong PW, Van de Werf F, White HD, Aylward PE, Wallentin L, Chen E, Lokhnygina Y, Whaley-Connell A, Habibi J, Rehmer N, Ardhanari S, Hayden MR, Pei J, Leronardi S, Rorick TL, Kilian AM, Jennings LH, Ambrosio G, Pulakat L, Krueger C, Ferrario CM, DeMarco VG, Sowers JR. Renin Bode C, Cequier A, Cornel JH, Diaz R, Erkan A, Huber K, Hudson inhibition and AT(1)R blockade improve metabolic signaling, MP, Jiang L, Jukema JW, Lewis BS, Lincoff AM, Motalescot G, oxidant stress and myocardial tissue remodeling. Metabolism Nicolau JC, Ogawa H, Pfisterer M, Prieto JC, Ruzyllo W, Sinnaeve 62(6):861-72, 2013. PR, Storey RF, Valgimigli M, Whellan DJ, Widimsky P, Strony J, Harrington RA, Mahaffey, KW, Aggarwal K. TRACER Investigators. Wu J, Mukerji R, Xie GY. Relationship of myocardial mechanics and Thrombin-receptor antagonist vorapaxar in acute coronary regional volume change in patients with left ventricular systolic syndromes. N Engl J Med. 2012 5;366(1):20-33. dysfunction. Int J Cardiovascular Imaging 2011;17:825-31. Uthamalingam S, Gurm GS, Ahmado I, Sidhu MS, Flynn J. Outcome Xu Y, Ma Y and Sun H. A novel approach to develop anti-virulence of patients with regadenoson-induced ST-segment depression agents against group A streptococcus. Virulence 2012;3(5):452-3. but normal perfusion on single-photon emission computed PMID:23076247 PMCID:PMC3485984 tomography. Epub head of print, 2012. Yerram P, Karuparthi PR, Chaudhary K. Pathogenesis and Uthamalingam S, Gurm GS, Sidhu MS, Verini DJ, Vorasettakarnkij management of renovascular hyptertension and ischemic Y, Engel LC, Blankstein R, Mamuya US, Hoffman U, Brady TJ, nephropathy. Minerva Urol Nefrol 2012;64(1):63-72. Cury RC, Ghoshhajra BB. Comparison of dual-source 64-slice adenosine stress CT perfusion with stress-gated SPECT-MPI for Zhang H, Dellsperger KC, Zhang C. The link between metabolic evaluation of left ventricular function and volumes. J Cardiovasc abnormalities and endothelial dysfunction in type 2 diabetes: an Comput Tomogr 2012;6(1):24-30. update. Basic Res Cardiol. 2012;107(1):237. Weachter R. Dabigatran: a new anticoagulant for stroke Zuidema MY, Dellsperger KC. Myocardial Stunning with prevention in patients with atrial fibrillation. Mo Med Hemodialysis: Clnical Challenges of the Cardiorenal Patient. 2012;109(2):146-9. Cardiorenal Med 2012;2(2): 125-133 E-pub ahead of print; 2012. Whaley-Connell A, Habibi J, Rehmer N, Ardhanari S, Hayden MR, Zuidema MY, Peyton K, Fay WP, Durante W, Korthuis, RJ: Pulakat L, Krueger C, Ferrario CM, Demarco VG, Sowers JR. Renin Antecedent hydrogen sulfide elicits an anti-inflammatory Inhibition and AT(1)R blockade improve metabolic signaling, phenotype in postischemic murine small intestine: Rol e oxidant stress and myocardial tissue remodeling. Metabolism of heme oxygenase-1. Am J Physiol Heart Circ Physiol 2013 Jan 23. Doi:pii: S0026-0495(12)00478-7. 10-1016/j. 2011;301:H888-H894. metabol.2012.12.012. Whaley-Connell A, Habibi J, Nistala R, Hayden MR, Pulakat L, Sinak C, Locher B, Ferrario CM, Sowers JR. Combination of direct renin inhibition with angiotensin type 1 receptor blockade improves aldosterone but does not improve kidney injury in the transgenic Ren2 rat. Regul Pept 176(1-3):36-44, 2012. Whaley-Connell A, Habibi J, Panfili Z, Hayden MR, Bagree S, Nistala R, Hyder S, Krueger B, Demarco V, Pulakat L, Ferrario CM, Parrish A, Sowers JR. Angiotensin II activation of mTOR results in tubulointerstitial fibrosis through loss of N-Cadherin. Am J Nephrol 34(2):115-25, 2011. Whaley-Connell A, Pulakat L, Demarco VG, Hayden MR, Habibi J, Henriksen EJ, Sowers JR. Overnutrition and the cardiorenal cardiovascular medicine books/chapters Aggarwal K. Cardiovascular Physiology: Pressure Volume Loops. In Specialty Board Reviews: Cardiology, R. Baliga (ed), McGraw Hill. 2011. Chan E and Alpert MA. Obesity cardiomyopathy: current views. In New Horizons in Cardiovascular Disease, A. Kimchi (ed), Bologna, Medimond Srl, 2012, 68-72. Chan E and Alpert MA. Cardiovascular physiology in obesity. In Critical Care Management of the Obese Patient, A. A. Solh (ed), Oxford, UK Wiley Blackwell Publishers, 2012, 3-12.

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