Modern Athlete Magazine Issue 127, February 2020 - Page 13
New JointEze Capsules
Providing Protection from
ointEze capsules now contains opti-MSM,
which is a proven highly bioavailable source
of sulphur, and the most researched MSM in
the world. Sulphur is important for several functions,
including support of connective tissue, skin health,
detoxification, immunity and metabolism. MSM also
reduces pain and inflammation caused by strenuous
activity, without any side effects. 1,2
Also, MSM protects the body from oxidative
damage by increasing the body’s natural antioxidant
capacity, enabling the body to neutralise damaging
free radicals. Strenuous exercise is associated
with generation of high levels of free radicals. The
decrease in inflammation and oxidative stress
protects joints from damage, helps the body recover,
boosts immunity and helps users stay mobile and
Sulphur is the third-most abundant mineral in the
human body, and is imperative for protein synthesis
and to help maintain healthy joints, tendons,
ligaments and other connective tissue. It is also
needed to support healthy homeostasis levels and
certain metabolic processes. 2
MSM is an organic sulphur compound
containing 34 percent sulphur by
weight. MSM’s sulphur can be readily
used in the body to help maintain sulphur levels.
MSM supports the body’s sources of two sulphur-
containing amino acids – methionine and cysteine.
Sulphur is also important for synthesising taurine,
S-adenosylmethione (SAME) and N-acetylcysteine
(NAC) – all imperative nutrients in the body. 2
One of the most important antioxidants, glutathione,
is needed to combat free radicals in the body,
and sulphur is required in the body to support the
synthesis of glutathione. 3,4 Consuming sulphur-
rich foods and sulphur-containing supplements,
including MSM, can help increase glutathione levels.
In one study, young men participating in an exercise
regimen took MSM for 10 days before running to
determine the effects on known markers of oxidative
stress. The study found that supplementing with
MSM significantly improved glutathione levels and
lessened markers of oxidative stress. 5
While MSM helps increase glutathione levels in the
body, it can also help inhibit inflammatory markers
through its anti-inflammatory properties. 6,7
Sulphur is an essential component of healing, and
a deficiency in the body may cause poor wound
healing. By supplementing with MSM, researchers
found it can support the healing process and lesson
inflammation caused by strenuous activity and
various conditions. 9 Studies found that MSM helps
lessen oxidative stress associated with exercise,
suggesting benefits for exercise recovery. 10 MSM
is also a methyl donor and has been studied to
determine its influence on lowering homocysteine
levels. Men who moderately trained took 3
grams of MSM for 30 days, finding that muscle
soreness and homocysteine levels decreased with
Studies continue to show the benefits associated
with regular MSM supplementation. What makes
JointEze even better is that it provides Opti-MSM in
conjunction with the nutrients zinc, copper, selenium
and magnesium, and just not Opti-MSM. This offers
great synergy, as MSM increases the body’s own
internal level of anti-oxidants (via glutathione) and
then the rest of the ingredients act as direct anti-
oxidants against free radicals.
MSM has been clinically proven to have the
following benefits to athletes, namely:Rreducing
muscle damage and soreness, combating exercise-
induced oxidative stress,
supporting the immune
system, and faster
Wong T, Bloomer R, Benjamin R, Buddington R. Small intestinal absorption of Methylsulfonylmethane (MSM) and accumulation of the sulphur moiety in selected tissues of mice. Nutrients. 2018; 10(1):19.
Parcell SW. Sulphur in human nutrition and applications in medicine. (Review: sulphur). Alternative medicine review. 2002 Febr 1;7(1):22-45.
Pizzorno JE, Katzinger JJ. Glutathione: Physiological and clinical relevance. J of restorative medicine 2012 Sept 1;1(1):24-37.
Grimbe RF. The effects of sulphur amino acids intake on immune function in humans. Journal of nutrition 2006. Jun 1:1:136(6):1660S-5S.
Nakhostin Roohi B, Barmaki S, Khoshkhahesh F, Bohlooli S. Effect of chronic supplementation with methylsulfonylmethane on oxidative stress following acute exercise in untrained healthy men. Journal of pharmacy and pharmacology. 2011 Oct;63(10):1290-4.
Lawrence T. The nuclear factor NF-B pathway in inflammation. Cold spring harbour perspectives in biology 2009. Octo 7:a001651
Ahn H, Kim J, Lee MJ, Kim YJ, Cho YW, Lee GS. Methylsulfonylmethane inhibits NLRP3 inflammasome activation. Cytokine. 2015 Febr 1,71(2):223-31.
Kim LS, Axelrod LJ, Howard P, Buratovich N, Walters FF. Efficiency of methylsulfunylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial, osteo arthritis and cartilage. 2006 Mar 1;14(3):286-94.
Butawan M, Benjamin R, Bloomer R. Methylsulfonylmethane: applications and safety of a novel dietary supplement. Nutrients. 2017; 9(3): 290.
Godwin S, Bloomer RJ, van der Merwe M, Benjamin R. MSM enhances LPS-induced inflammatory response after exercise. Journal of the international society of sports nutrition. 2015 Dec 1:12(S1):P48.
Kalman DS, Feldman S, Scheinberg AR et al. Influence of methylsulfonylmethane on markers of exercise recovery and performance in healthy men: a pilot study. Journal Int Soc Sports Nutr 2012; 9(1):46.