MMRF Accelerator Magazine Summer 2016 Edition | Page 10

Empliciti™ / Pomalyst ® / Dex A study of Empliciti ( elotuzumab ) in combination with Pomalyst ( pomalidomide ) and low dose dexamethasone ( dex ) is open for multiple myeloma patients who have relapsed after or are refractory to a prior treatment with a Revlimid ® ( lenalidomide ) based regimen . This is an interventional Phase II , multi-center , open-label , single arm study to assess the safety and efficacy of this combination therapy . Based on patient response , this therapy could potentially serve as a possible second or third line treatment regimen after Revlimid stops working .

Empliciti™ / Pomalyst ® / Velcade ® / Dex A study of Empliciti ( elotuzumab ) in combination with Pomalyst ( pomalidomide ), Velcade ( bortezomib ) and dexamethasone is open for patients who have received at least two prior therapies and are relapsed and / or refractory to both lenalidomide and bortezomib . This is an interventional Phase II , multi-center , open-label , single arm study to assess the safety and efficacy , and evaluate the objective response rate ( partial response or better ), of elotuzumab in combination with pomalidomide , bortezomib , and dexamethasone .

Ninlaro ® and Dex vs . Ninlaro ® , Dex and Revlimid ® ; Randomized with NFKB2 Rearrangement This interventional , randomized , Phase II , single-center trial is for patients with multiple myeloma that has returned after a period of improvement or who do not respond to treatment . It studies how well Ninlaro ( ixazomib citrate ) and dexamethasone or Ninlaro , dexamethasone and Revlimid ( lenalidomide ) work based on the presence of the rearrangement of a gene called nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 ( NFKB2 ) in treating .

Questions about clinical trials ? Please call our MMRF Nurse Specialists at 1-800-603-6628 . To search for clinical trials visit myelomatrials . org

Phase I Phase I / II

Phase II

New Dx ./ Transplant

PDL-1 / Revlimid ( Same trial ) ( Post-Transplant )

Ninlaro / Revlimid / Dex Transplant WU = Washington University • UC = University of Chicago

SMM

Darzalex Empliciti / Dex / Revlimid

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