MMRF Accelerator Magazine Summer 2015 Edition | Page 6

Established and experimental treatments Drug classes, and the number of treatments within them, are on the increase. Treatments can be classified based on similarities in behavior, similarities in chemical structure, and by the way they are used Immunotherapies and Antibodies In Development n Monoclonal Antibodies  Immunotherapy is the newest approach (e.g., anti-CD 38 inhibitors, to multiple myeloma treatment. It is an checkpoint inhibitors, etc.) umbrella term that describes different n  to treat a particular condition. ways to stimulate the immune system n  Treatments are particularly and enhance its ability to attack cancer effective when drugs from different classes are given Vaccines Adoptive T-cell therapy cells. Many of these treatments involve In Phase 3 antibodies that target specific proteins n (monoclonal antibody) found on multiple myeloma cells. These simultaneously, in combinations drugs are still in clinical trials but show of two or three. considerable promise. Daratumumab  n Elotuzumab (monoclonal antibody)  Researchers are finding ways to enable immune cells to attack cancer cells. 6 T HE MMRF.ORG