Mitochondria
Monthly
Interference of Oxidative Phosphorlylation
This is likely to cause severe problems because unlike nuclear DNA, mtDNA doesn’t include much non coding DNA which makes it more likely for deleted regions to be crucial. Mitochondrial DNA contains 37 genes and each codes for one of seven things; complex I, complex III, cytochrome C, ATP synthase, ribosomal RNA, or transfer RNA. Each of these proteins is crucial for the ETC and production of ATP.
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The DNA polymerase of the mitochondria known as pol y works in conjunction with a protein known as twinkle to replicate and maintain mtDNA.
Free floating nucleotides that are used for the replication of mitochondrial DNA or mtDNA are synthesizes with the help of an enzyme known as ribonucleotide reductase.
Patients who have been diagnosed with CPEO can have one or more of mutation leading to a defect in these protein as well as defective adenine nucleotide translocase all of which ultimately leading to a small or large deletion of mtDNA when replicated.
DNA Polymerase-Four Key Characteristics for PCR. (n.d.). Retrieved January 01, 2018, from https://www.thermofisher.com/ca/en/home/life-science/cloning/cloning-learning-center/invitrogen-school-of-molecular-biology/pcr-education/pcr-reagents-enzymes/dna-polymerase-characteristics.html