Your Bedding
Read: Your pillows and comforter — since you should obviously be cleaning things like pillowcases and sheets every two weeks. These fluffy sleeping accessories should be thrown into your washing machine (just reach the manufacturer's label first!) two to three times per year.
Your Mattress
The perfect time to pay attention to what's under your bedding? When your sheets and comforter are being washed, too. Use your vacuum's crevice tool to clean the surface and sides, then spot-clean stains with an upholstery cleaners. Sanitize with a spritz of disinfectant spray afterwards and you're all set.