Shedding Light on Precision Care : Photodynamic Therapy Catheter Delivery System for Antibiotic-Resistant Abscesses
by KHOI DO , BS , YEDARM KIM , BS , INGRID OKONTA , BS , MS , & ERIC SCHOEN , MD
Introduction
Photodynamic Therapy ( PDT ) has emerged as a promising modality in the treatment of antibiotic-resistant abscesses , offering a targeted and effective approach to combat microbial resistance . The rise of antibiotic resistance has posed significant challenges in managing infectious diseases , necessitating innovative strategies like PDT for improved patient outcomes . By harnessing the power of light-activated photosensitizers , PDT forms reactive oxygen species ( ROS ) that selectively destroy pathogenic microbes while minimizing damage to surrounding healthy tissue , making it a compelling alternative in the era of escalating antibiotic resistance . A small number of Phase 1 trials in humans have begun over the last several years .
In the fast-evolving landscape of interventional radiology , innovative solutions are continually emerging to tackle complex medical challenges . At the forefront of this movement is Bluegrass Biodesign , a pioneering program led by medical students dedicated to identifying and addressing real medical problems through the development of novel devices . Our recent project within this program has focused on advancing treatment options for antibiotic-resistant and multiloculated abscesses using PDT , aiming to revolutionize therapeutic outcomes .
The Issue and Its Importance
Antimicrobial resistance ( AMR ) represents a looming global health crisis . In 2014 , it was estimated that AMR caused approximately 700,000 annual global deaths . Alarmingly , a recent study published in The Lancet estimated that 1.27 million annual global deaths were directly attributable to AMR in 2019 . Looking ahead , predictions suggest that AMR could cause 10 million deaths per year by 2050 if current trends continue . 1 , 2 These figures underscore the urgency of developing innovative treatments to combat AMR and reduce
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