Louisville Medicine Volume 62, Issue 6 | Page 23

reported and were significantly lower when compared to 61/280 (21.8%, 95%CI 17-27) in the post –KASPER period. Non-heroin deaths were significantly greater in the pre-KASPER period 94/97 (94%)(95% CI =90.88-99.38) P=<0.001 than in the post-KASPER period 219/280 (78.21%) (95% CI =82.68-94). The percentage of fatal overdose deaths in the two time periods did not change significantly. Post-KASPER overdose deaths 280/1316 (21.3%) 95% CI 19-23 vs 97/510 (19.2%) 95% CI = 16-22% of pre-KASPER overdose deaths (table 1). The top 10 causes of death in the entire sample are seen in table 1a. Drug O.D. deaths were the most frequently listed cause of death followed by myocardial infarction. Motor vehicle accident deaths, cancer and suicide deaths completed the top five causes of death in the post-KASPER period. Respiratory failure deaths did not make the top 10 list of causes of death in the pre-KASPER period; this was the seventh leading cause of death in the post KASPER period. The increase in respiratory deaths can be explained by the increase in the use of heroin and its effects on respiration. It became clear t