HEALTH
HEALTH
Titila Mputa will participate in the initial phase of the study : “ You doing this can help create an HIV-free generation .”
She is HIV-negative , so she volunteered to participate in the initial phases of the study that cleared the way for HVTN 702 .
How HIV spread around the world
She knows it ’ s too late for her family and for many in her generation but is excited to be able to help ensure that there ’ s hope for the next .
“ You get to be the superhero that you want to be ,” Mputa said . “ You doing this can help a thousand people out there . You doing this can help create an HIV-free generation .”
How HIV spread across the West
The infection feigned a role as new and unknown but had established itself as a pandemic in other parts of the world , without anyone realizing .
Teenager controls HIV infection without drugs for more than 12 years
Though the roots of the virus were soon discovered to lie in Africa , where a range of subtypes exist , one in particular -- subtype B -- was spreading rapidly around the globe , particularly in the West , and just how it spread was largely unknown -- until now .
Scientists at the University of Oxford recently solved part of this mystery by analyzing thousands of genome sequences from viruses isolated in different parts of the world . Their study revealed North America to play an influential role in the pandemic and Europe to have been influenced , with the virus arriving in droves from other regions .
“ Europe was absorbing the virus ,” said Gkikas Magiorkinis , a medical virologist at the University of Oxford who led the study . “ North America was actively letting the virus out .”
North America was seen to be spreading the virus much more than importing it by transmitting it out of the continent and into Western Europe on multiple occasions .
“ It wasn ’ t just a random transition or single point of introduction ; it was happening constantly ,” Magiorkinis said . He stressed that these are movements of the virus , not migrants . “ It ’ s not immigrants causing this , as people going on holiday can get infected .”
This continuous flow is , in part , thought to be due to certain countries being more influential than others , such as those in North America . A country is considered influential by having many connections to other parts of the world , as once any virus enters , it can then easily spread .
“ It was only when it entered the USA that it became a pandemic ,” Magiorkinis said . In contrast , Europe was
“ The critical issue is population-mixing and the fact people acquire , or spread , viruses associated with travel ,” said Chris Beyrer , professor of public health and human rights at the Johns Hopkins Bloomberg School of Public Health . found to have absorbed constant flows of the virus from multiple regions of the world , including the United States .
“ Within Europe , three countries had higher connections : the UK , France and Switzerland ,” Magiorkinis said . These connections saw these countries both releasing and absorbing the virus , but with greater numbers coming in , including from the United States .
“ The critical issue is population-mixing and the fact people acquire , or spread , viruses associated with travel ,” said Chris Beyrer , professor of public health and human rights at the Johns Hopkins Bloomberg School of Public Health . “ There ’ s a long history of blame for the spread of the epidemic ... but you have to improve control and treatment .”
Multiple studies have shown the benefits of antiretroviral treatment in preventing transmission of HIV as levels of the virus can become undetectable once on treatment .
After arriving in Europe , the virus soon spread within the continent but with a clear segregation between Eastern and Western Europe as each side evolved its own pockets of the epidemic . In Western Europe ( as well as North America ), HIV mainly affects gay communities , causing concentrated epidemics . In the UK , more than half of new HIV infections occurred among gay men in 2014 , despite them making up an estimated 2 % to 3 % of the male population . But in Eastern Europe , the virus mainly infects injecting drug users , and transmission dynamics are quite different , as the virus is not spread sexually .
This segregation of epidemics occurred until the collapse of the Soviet Union in the 1990s , when movement -- and transmission --promptly changed .
“ When the Soviet Union fell , we can see the virus in that area spilled over into Western Europe , probably due to migration ,” Magiorkinis said .
What it means
The study was hypothetical and based on genetic analysis , so they cannot be proved . Beyrer also stresses that the Oxford team ’ s findings have their limitations : “ It ’ s a huge pandemic , and huge numbers
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