environmental health
Figure 1: GC-MS analysis with HP-5ms column( Agilent) of 100 µ g / mL Fentanyl( in acetonitrile, Lot 483337, Cayman Chemical)
Chemical No. ISO60197). The GC performance specification yielded a retention time on a HP-5ms column of ca. 15.05min, with a precision( as CV) of 0.1 %. Thus, both the GC-MS sensitivity and GC specificity are excellent for detection of fentanyl in test samples.
Finally, a characteristic Fourier transform infrared spectroscopy( FT-IR) profile was determined from the deposited fentanyl hydrochloride salt using a benchtop FT-IR system( see Figure 2). An example that illustrates the detection of synthetic opioids was a suspected CDS white powder found within a rolled-up bill. The material quantity was minute; however, even small amounts of the drug are still highly toxic. Donned in full PPE, including gloves, lab coat and an N95 mask, the material was removed, diluted in acetonitrile, centrifuged and filtered( see Figure 3).
Going Forward
As emerging synthetic drugs appear on the streets, DC DFS PHL intends to update the database and methods to ensure coverage of new substances. Working with the OAG, new legislation will continue to evolve to address new synthetic drugs in a consistent and systematic way, as seen with the SAFE DC Bill of 2015. Future research will be to study correlations of toxicological reports with drugs identified at the scene or within the area, providing valuable feedback to evaluate the effectiveness of drug screens and provide advance notice to local toxicologists of emerging drugs of abuse.
Figure 2: FT-IR analysis of deposited 500 µ L of 100 µ g / mL Fentanyl-HCl, after evaporation( Spectrum II, Perkin Elmer)
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Figure 3: Analysis of suspected CDS white powder, containing Fentanyl and Heroin( other non-CDS noted) |
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Winter 2017 LAB MATTERS 25 |