Keyhole Limpet Hemocyanin Market Research Report and Forecast Keyhole Limpet Hemocyanin (KLH) Market - Global In

Keyhole Limpet Hemocyanin (KLH) Market -
Global Industry Analysis, Size, Share, Growth,
Trends, and Forecast 2017 - 2025
Keyhole limpet is a species hailing from the Northeast Pacific belonging to the
Fissurellidae family. It is scientifically referred to as “megathura crenulata”, which is
a monotypic genus. This species is found in the rocky coast of western North
America and Mexico. Keyhole limpet hemocyanin (KLH) is a respiratory protein
similar to hemoglobin in humans. It belongs to an oxygen-containing metalloprotein
family found in hemolymph. A liter of blood from the keyhole limpet generally
produces 20 grams of hemocyanin. There are two types of protein – KLH1 and KLH2
– which are around 60% similar on a structural level. Both exhibit a molecular
weight 3,90,000 Daltons and consist of 3,400 amino acids in protein structure.
Keyhole limpet hemocyanin is a copper-containing protein used in several medical
applications. It is potentially immunogenic but does not cause any adverse immune
response in humans. Keyhole limpet hemocyanin is available only in purified
biological product form as it cannot be manufactured synthetically. The steps of
purification include precipitation, dialysis, and chromatographic purification. Keyhole
limpet hemocyanin is used extensively as a carrier protein in biotechnological
applications. It also finds therapeutic and pharmaceutical applications. This protein
is used in vaccine production as a vaccine carrier protein. It also exhibits anti-cancer
activity in bladder carcinoma and has been tested in a variety of cancer vaccines
which include cutaneous melanoma, non-honking lymphoma, and breast cancer.
KLH is considered a complex protein to work with because of its property to
precipitate and aggregate. It is a commonly used carrier in peptide conjugation for
antibody production. Clinical trials are conducted by several pharmaceutical
companies in order to discover new applications of keyhole limpet hemocyanin in
immunotherapy.
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limpet-hemocyanin-market.html
The clinical evaluation of the current applications of keyhole limpet hemocyanin
remains an integral area for future research. High awareness in pharmaceutical and
biotech companies about the therapeutic capabilities of keyhole limpet hemocyanin
drives this market. The rapidly developing market for therapeutic vaccines for
cancer and the proven efficacy of KLH as a carrier protein are expected to create
significant potential for the pharmaceutical market, besides the optimal use of KLH
in humoral immune response assay in human serum. The costly procedure of
retrieving keyhole limpet hemocyanin however leads to the sluggish development of