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Effect of kinesio taping in chronic non-specific low back pain Although a variety of studies demonstrate the effect of KT on pain relief, functional performance, disability and improvement in ADL, the specific mechanism of action of KT remains unclear. Possible explanations for the mechanism of pain relief are that KT can ef- fectively increase the kinesio taping may provide force on skin and increase the gap which is underneath the skin or the gap between epidermis and dermis, pro- mote subcutaneous blood and lymphatic reflux, and accelerate the healing of injured areas through its own natural tension. In addition, KT can produce conti- nuous sensory input to the skin sensors, which may relatively suppress the sensory input of pain perception (32). An additional possible explanation for functional performance, disability or improvements in ADL is that application of KT may increase the range of motion of the temporomandibular joint during exercise (33). Study limitations Although this study resulted in some meaningful implications, it also has several limitations. First, a limited number of studies were included; there is a need for more high-quality RCT studies with large sample sizes to confirm the reliability of the present study. Secondly, the total quality of included studies was rated as moderate, and overall confidence in the VAS and ODI estimates was low, which may lead to overesti- mation of effect and reduction in the recommendation rate of our pooled results. Thirdly, because there are few RCTs on this topic, this supports the inclusion of other measures of pain and disability, and since we only investigated VAS and ODI measures to assess the pain and disability, it is possible that relevant stu- dies may have been missed. Fourthly, methodological heterogeneity occurred in many included studies, with comparisons between different intervention strategies, and several studies assessed the combined effect of KT and other intervention strategies. Thus, further studies are needed to compare KT separately with some speci- fic general interventions. Finally, the shape, direction and tensile force of KT for pain reduction or functional performance are different in different individuals (34). Further studies, focusing on the effect on pain reduc- tion or improvement in functional performance using different shapes, directions or tensile forces of KT, should be included in the analysis. Conclusion This meta-analysis demonstrated that KT, either sepa- rately or in combination with other general therapies, resulted in greater pain relief and improvement in ADL in patients with CNSLBP than did general physical therapies without KT. 739 ACKNOWLEDGEMENTS This study was supported by the programme of Shanghai Science and Technology Committee (No.16411955200) and Scientific Research and Innovation Team Funding Plan of Shanghai Sanda University. The authors have no conflicts of interest to declare. REFERENCES 1. Gordon R, Bloxham S. A systematic review of the effects of exercise and physical activity on non-specific chronic low back pain. Healthcare (Basel) 2016; 4 (2): ii: E22. 2. Hoy D, Bain C, Williams G, March L, Brooks P, Blyth F, et al. A systematic review of the global prevalence of low back pain. Arthritis Rheum 2012; 64: 2028–2037. 3. Brauer S. Chronic non-specific low back pain. Austral J Physiother 2007; 53: 67. 4. DePalma MJ, Ketchum JM, Saullo T. 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