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jcda ca ESSENTIAL DENTAL KNOWLEDGE Published by The Canadian Dental Association jadc DES CONNAISSANCES DENTAIRES INDISPENSABLES Publié par Diagnostic Applied Challenge Research Cite this article as: J Can Dent Assoc 2013;79:d88 l’Association dentaire canadienne Solitary Gingival Lesion in an Adolescent Catherine Grenier, DMD, MSc, FRCD(C); Carl Bouchard, DMD, MSc, FRCD(C); Sylvie Louise Avon, DMD, PhD, FRCD(C) Case Presentation Figure 1: Intraoral view showing the gingival lesion on the buccal aspect of tooth 45. Figure 2: Tissue fragment characterized by epithelium with a lightly undulating surface overlying connective tissue containing numerous lymphatic vessels (hematoxylin and eosin, magnification 10×). jcda ca | 2014 | Vol. 80, No. 1 | ESSENTIAL DENTAL KNOWLEDGE Published by The Canadian Dental Association jcdaf ca What is the diagnosis? A 14-year-old girl with a papillarylike lesion of the buccal gingiva in the lower right premolar region (Fig. 1) was referred to a private oral and maxillofacial surgery office. The lesion had been discovered by chance during a routine examination by the patient’s general dentist. The patient’s medical history was unremarkable: she did not smoke, was not taking any medications and did not report having any allergies. Intraoral examination revealed an erythematous lesion, soft on palpation, measuring less than 1 cm on the gingiva of the buccal aspect of tooth 45. No other lesion was found. An excisional biopsy was performed the day of the consultation. The specimen was immediately placed in 10% formalin solution and sent for histologic examination. Microscopic evaluation revealed tissue fragments characterized by stratified squamous epithelium overlying connective tissue stroma containing vessels of diverse shapes and sizes. The surface epithelium was undulated due to infiltration of the epithelial tissue by lymphatic vessels (Fig. 2). Differential diagnosis included a histopathological evaluation to rule out verrucous xanthoma. Microscopic evaluation revealed no epithelial hyperplasia or foamy hictiocytes (xanthoma cells) between rete pegs in the upper connective tissue, which would have been indicative of verrucous xanthoma. Localized juvenile spongiotic gingival hyperplasia was also ruled out, as the microscopic results did not match the condition’s histopathology—epithelial hyperplasia, severe spongiosis and a mixed inflammatory infiltrate in the chorion. The lymphatic origin of the vessels was confirmed by the absence of erythrocytes in their lumen (Fig.  3). This information led to a diagnosis of lymphangioma. Lymphang