Figure 1: Conservation of Human Pentraxins (Source;Original)
In terms of amino acid sequence identity, hSAP is shown to be closely related to hCRP (figure 1) with 50.1%
amino acid similarity. On the other hand, hPTX4 has 30.5% homology with hCRP, while hPTX3 has only 28.5%
homology. In addition to conservation within the human evolution, CRP is known to be conserved across many
species. Atlantic Horseshoe Crab has the most evolutionarily conserved CRP, while Rabbit CRP has the highest
amino acid homology with hCRP as shown in figure 2. Furthermore, Rabbit has 75.7% amino acid similarity
with hCRP, while Guinea Pig has 73.7%, Rat has 67.2%, African Clawed Frog has 44.7% and the African
Horseshoe Crab has 29.1%.
Figure 2 Conservation of CRP of various species (Source;Original)
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