I have identified 6 primary mechanisms for this suppression and
there are several secondary mechanisms.
This leads to chronic
cerebral glucose deprivation, to
increased cerebral hunger and to
consumption of the same foods
with the same result, and so the
cycle repeats again and again and
again...leading to increased risk of
obesity/diabetes and heart disease.
Note that the initiating and driving
influence is chronic cerebral glucose
deprivation or hunger, and that can
cause incipient dementia (not the
reverse as is usually assumed by
tamine cycle -- is housed in glial
cells and is driven by the enzyme
glutamine synthetase.
However
it is not the threat of hypoglycaemia that is the major metabolic
problem in modern humans – it
is hyperglycaemia, resulting from
consumption of excess refined carbohydrates and sugars. This leads
in turn to chronic hyperinsulinism.
Both hyperglycaemia and hyperinsulinism trigger and suppress the
cerebral glucose pump and therefore prevent glucose entry to the
brain – in other words they short
circuit the brain.
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