iS Skin Source 2021 Q3 | Page 53

DNA PROTECTION
The use of Extremozymes was pioneered by iS Clinical and advanced the aesthetics industry , thus helping consumers . In addition to the sunscreen actives , these Extremozymes that are sourced from extremophilic plants living in very harsh environments help protect the skin ’ s vital structures like DNA . This protection was published for Extreme Protect SPF 30 in the Journal of Cosmetic Dermatology . 14
The skin biopsy below demonstrates DNA photoprotection conveyed by Extreme Protect SPF 40 when applied prior to sun exposure . Sunburn cells , a “ solar signature ” of DNA photodamage , are numerous on the biopsy without protection from the sunscreen . No sunburn cells are seen on the biopsy of the skin to which Extreme Protect SPF 40 was applied prior to sun exposure .
PROTECTION FROM INTERNAL FREE RADICAL SOURCES
All living cells generate energy in order to function and thereby suffer some amount of oxidative stress . For skin , the majority of free radical damage comes from sunlight . However , skin also experiences free radical damage from ongoing internal metabolism . The below evidence demonstrates that Extreme Protect SPF 30 also offers protection from internal free radical sources . 15 In addition to neutralizing
Skin was exposed to full spectrum sunlight ( UVA + UVB ) No EXTREME PROTECT SPF 40 Many sunburn cells seen — indicates DNA damage
EXTREME PROTECT SPF 40 applied 1 hour before sun exposure No sunburn cells seen — indicates DNA protection

All living cells generate energy in order to function and thereby suffer some amount of oxidative stress .

free radicals from sunlight , Extreme Protect SPF 30 also neutralized thymine dimers generated by internal free radical metabolism ( note 3 rd bar to the right below ). The negative control below shows skin in the dark – no sun exposure but free radical damage from
14 DeHaven C , Hayden PJ , Armento A , Oldach J . Photoprotection conveyed by sunscreen . J Cosmetic Dermatol . 2014 . 13 : 99-102 . 15 DeHaven C , et . al . 2014 . Ibid .
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