and Orentreich developed the concept of “ subcision ,” the use of hypodermic needles to induce wound healing in depressed cutaneous scars . 2
To further discuss the mechanism of action of this process , let us explore how these microinjuries , using microneedles , produce a controlled skin injury without collectively damaging the epidermis .
During the microneedling procedure , the needles penetrate the stratum corneum and create small holes , known as micropunctures , with minimal damage to the epidermis . This sequentially leads to the generation of growth factors that stimulate the production of collagen and elastin in the papillary layer of the dermis . 3 Collagen and elastin are the main fibers forming the extracellular matrix . Both are produced by fibroblasts . Collagen is responsible for tensile strength , and elastin provides elasticity to the skin . Production and density of both colla-
3 Doddaballapur S . Microneedling with dermaroller . J Cutan Aesthet Surg . 2009 ; 2 ( 2 ): 110 – 111 .
2 Orentreich DS , Orentreich N . Subcutaneous incisionless ( subcision ) surgery for the correction of depressed scars and wrinkles . Dermatol Surg . 1995 ; 21 ( 6 ): 543 – 549 .