Issue 33.1
The device works by scanning the back of the eye where the optic nerve sits .
Because the optic nerve is so closely linked to the brain , it carries the same biological information in the form of protein and lipid biomarkers .
These biomarkers exist in a very tightly regulated balance , meaning even the slightest change may have serious effects on the ‘ brain-health ’. TBI causes these biomarkers to change , indicating that something is wrong .
Previous research has demonstrated the technology can accurately detect the changes in animal brain and eye tissues with different levels of brain injuries -- picking up the slightest changes .
The device detailed in the current paper detects and analyses the composition and balance of these biomarkers to create ‘ molecular fingerprints ’.
The current study details the development , manufacture , and optimisation of a proofof-concept prototype , and its use in reading biochemical fingerprints of brain injury on the optic nerve , to see whether it is a viable and effective approach for initial ‘ on the scene ’ diagnosis of TBI .
The researchers constructed a phantom eye to test its alignment and ability to focus on the back of the eye , used animal tissue to test whether it could discern between TBI and non-TBI states , and also developed decision support tools for the device , using AI , to rapidly classify TBIs .
The device is now ready for further evaluation including clinical feasibility and efficacy studies , and patient acceptability .
The researchers expect the diagnostic device to be developed into a portable technology which is suitable for use in point-of-care conditions capable to rapidly determine whether TBI occurs as well as classify whether it is mild , moderate or severe , and therefore , direct triage appropriately and in timely manner . g
High School Students with Multiple Concussions Report Increased Suicidal Behavior
High school students , particularly males , who reported a history of concussion in the last year were more likely to engage in suicidal thoughts , planning or attempts than their nonconcussed peers , according to a study by a research team that includes a researcher at the University of Michigan .
Male teens who reported two or more concussions in the past year were twice as likely to report a suicide attempt than males who reported one concussion . Increased odds of suicidal behaviors were similar for females regardless of concussion frequency .
“ This type of research is never easy to discuss , but it is vitally important to understand who is at risk and why ,” said study co-author Steve Broglio , professor of kinesiology and director of the University of Michigan Concussion Center . “ Anyone who has concern for any student-athlete should not be afraid to reach out and help find the appropriate resources .”
This is believed to be the first known study to examine the relationship between suicidal behaviors and concussion frequency in a nationally representative sample of U . S . high school students .
“ From broader literature we know that brain injuries , like concussion , can precipitate or exacerbate mental health challenges ,” said lead author Jacob Kay , rehabilitation scientist at Prisma Health Children ’ s Hospital and the University of South Carolina . “ Our study further highlights the importance of evaluating mental health among both male and female youth that have sustained a concussion . This is particularly true for those who have sustained multiple concussions in a short time .” g
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