Contents
Preface ix
Section I Structures & Functions of Proteins & Enzymes 1
10 The Biochemical Roles of Transition Metals 96
Peter J. Kennelly, PhD
1 Biochemistry & Medicine 1
Víctor W. Rodwell, PhD
2 Water & pH 6
Peter J. Kennelly, PhD, & Víctor W. Rodwell, PhD
Amino Acids & Peptides 15
Peter J. Kennelly, PhD, & Víctor W. Rodwell, PhD
4 Proteins: Determinaron of Primary Structure 24
Peter J. Kennelly, PhD, & Víctor W. Rodwell, PhD
5 Proteins: Higher Orders of Structure 34
Section III Bioenergetics 109
11 Bioenergetics: The Role of ATP 109
Kathleen M. Botham, PhD, DSc, & Peter A. Mayes. PhD. DSc
12 Biologic Oxidation 115
Kathleen M. Botham, PhD, DSc, & Peter A. Mayes, PhD. DSc
13 The Respiratory Chain & Oxidative Phosphorylation 121
Kathleen M. Botham, PhD, DSc, & Peter A. Mayes, PhD, DSc
Peter J. Kennelly, PhD, & Víctor W. Rodwell, PhD
Section II Enzymes: Kinetics, Mechanism, Regulation, & Role of Transition Metals 49
6 Proteins: Myoglobin & Hemoglobin 49 Peter J. Kennelly. PhD, & Víctor W. Rodwell, PhD
7 Enzymes: Mechanism of Action 59
Peter J. Kennelly, PhD, & Víctor W. Rodwell, PhD
8 Enzymes: Kinetics 71
Section IV Metabolism of Carbohydrates 133
14 Overview of Metabolism & the Provision of Metabolic Fuels 133
Owen P. McGuinness, PhD
15 Saccharides( ie, Carbohydrates) of Physiological Significance 147
Owen P. McGuinness, PhD
Víctor W. Rodwell, PhD
9 Enzymes: Regulation of Activities 85 Peter J. Kennelly, PhD, & Victor W. Rodwell, PhD
16 The Citric Acid Cycle: A Pathway Central to Carbohydrate, Lipid, & Amino Acid Metabolism 156
Owen P McGuinness, PhD