IASLC Sept 2013

Appendix 1 No. of NSCLC* No. (%) ALK+ 0 0 0 0 0 0 0 5 0 0 0 0 0 0 75 29 27(6.8%) 101 10 (9.9%) 292 0 0 0 2 (6.9%) 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 23 0 9 8 0 27 12 48 0 0 0 0 2 (8.7%) 0 0 0 0 0 0 1 (2.1%) 0 0 24 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Never-smokers with adenocarcinoma Never-smokers Non/light smokers, Asian, women 1 (25%) NE Ca included SCLC + LCNEC 0 0 0 0 No. No (%) Patient NE??Ca ALK+ Selection 103 75 305 603 77 340 335 120 358 141 130 266 254 109 107 52 313 103 735 101 10 (9.9%) 28 (3.8%) 395 12 (11.7%) 62 5 (1.6%) 211 5 (2.4%) 10 (16.1%) 3 (5.8%) 52 3 (5.8%) 3 (2.8%) 69 3 (4.3%) 30 7 (6.4%) 82 7 (8.5%) 18 8 (3.1%) 254 8 (3.1%) 0 0 13 (4.9%) 209 11 (5.3%) 34 0 4 (3.1%) 130 4 (3.1%) 0 0 0 19 (13.5%) 130 18 (12.8%) 2 0 4 20 (5.6%) 358 20 (5.6%) 0 0 0 0 9 (7.5%) 63 3 (4.8%) 48 4 (8.3%) 2 2 (100%) 7 6 (1.8%) 185 5 (2.7%) 150 1 (0.7%) 0 0 0 11 (3.2%) 253 11 (4.3%) 71 0 7 0 9 2 (2.6%) 50 2 (4.0%) 20 0 3 0 4 16 (2.7%) 8 (2.6%) 208 8 (3.8%) 88 0 9 0 0 5 (6.7%) 20 2 (10.0%) 11 1 (9.1%) 2 0 42 4 (4%) No. (%) ALK+ No. of ADC No. (%) ALK+ No. of SCC No. (%) No. ALK+ ADSC No (%) ALK+ No. NSCLC, others Summary of Published Studies on ALK ?Gene Rearrangement Testing in Lung Cancer Study Country Test Platform Rikova et al., 2007 China RT-PCR Soda et al., 2007 Japan RT-PCR Koivunen et al., 2008 US/Korea RT-PCR Perner et al., 2008 US/Switzerland FISH/RT-PCR Shinmura et al., 2008 Japan RT-PCR/Gen Seq Takeuchi et al., 2008 Japan RT-PCR/FISH/Gen Seq Boland et al., 2009 US IHC/FISH/RT-PCR Martelli et al., 2009 Italy/Spain RT-PCR/FISH/IHC 74 Rodig et al., 2009 US IHC/FISH Shaw et al., 2009 US FISH Takeuchi et al., 2009 Japan IHC/RT-PCR & FISH IASLC ATLAS OF ALK TESTING IN LUNG CANCER Wong et al., 2009 China (HK) RT-PCR Jokoji et al., 2010 Japan IHC Sakairi et al., 2010 Japan IHC/FISH & RT-PCR Salido et al., 2010 Spain FISH/IHC Sun Y et al., 2010 China RT-PCR Takahashi et al., 2010 Japan RT-PCR/Direct Seq Zhang X et al., 2010 China RACE/ RT-PCR Paik et al., 2011 Korea IHC/FISH Yi et al., 2011 US FISH/IHC

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