HPE Chinese Human albumin handbook | Page 14

计学意义 。 其中自蛋白的起始剂量 1g / kg , 根据中心静 脉压和 ( 或 ) 容量过度负荷给予 20-40g / d , 直至停用特 利加压素 。 关于 2 型 HRS 患者应用血管收缩剂加白蛋 白的信息非常有限 , 尽管联合治疗可改善肾功能 , 停药 之后的 HRS 复发率仍非常高 。
总结
总而言之 , 由于临床对 HA 认识的深入以及适应证 的增多 , HA 的临床应用出现了一些误区 。 随着循证医 学方法学的发展和临床指南制订的规范 , 在肝脏病学领 域 , RCT 和 meta 分析已经表明 HA 在治疗肝硬化腹水 、 预防大量放腹水之后循环功能障碍 、 预防自发性细菌性
腹膜炎所致的肾衰竭以及与血管收缩剂联合用于治疗肝 肾综合征的疗效 , 以及用于治疗或预防其他肝硬化的严 重并发症 。 然而大部分的研究数据基本来源于欧洲国 家 , 中国医生在解读和应用这些证据时应结合我国的医 疗情况 、 患者的意愿 、 卫生经济学的评价等等 。 除了部 分血容量扩充的作用可以为人工胶体所替代 , 考虑到输 注血液制品的安全性 、 资源获得的有限性以及药品的经 济性 , 应规范 HA 的合理应用 , 避免医疗资源的浪费 。
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