HPE Chinese Human albumin handbook - Page 14

计学意义 。 其中自蛋白的起始剂量 1g / kg , 根据中心静 脉压和 ( 或 ) 容量过度负荷给予 20-40g / d , 直至停用特 利加压素 。 关于 2 型 HRS 患者应用血管收缩剂加白蛋 白的信息非常有限 , 尽管联合治疗可改善肾功能 , 停药 之后的 HRS 复发率仍非常高 。
总结
总而言之 , 由于临床对 HA 认识的深入以及适应证 的增多 , HA 的临床应用出现了一些误区 。 随着循证医 学方法学的发展和临床指南制订的规范 , 在肝脏病学领 域 , RCT 和 meta 分析已经表明 HA 在治疗肝硬化腹水 、 预防大量放腹水之后循环功能障碍 、 预防自发性细菌性
腹膜炎所致的肾衰竭以及与血管收缩剂联合用于治疗肝 肾综合征的疗效 , 以及用于治疗或预防其他肝硬化的严 重并发症 。 然而大部分的研究数据基本来源于欧洲国 家 , 中国医生在解读和应用这些证据时应结合我国的医 疗情况 、 患者的意愿 、 卫生经济学的评价等等 。 除了部 分血容量扩充的作用可以为人工胶体所替代 , 考虑到输 注血液制品的安全性 、 资源获得的有限性以及药品的经 济性 , 应规范 HA 的合理应用 , 避免医疗资源的浪费 。
References 1 Cochran A et al . Burn patient characteristics and outcomes following resuscitation with albumin . Burns 2007 ; 33 ( 1 ): 25 – 30 . 2 Balasch J et al . Neurohormonal and hemodynamic changes in severe cases of the ovarian hyperstimulation syndrome . Ann Intern Med 1994 ; 121 ( 1 ): 27 – 33 . 3 Cochrane Injuries Group Albumin Reviewers et al . Human albumin administration in critically ill patients : systematic review of randomised controlled trials . BMJ 1998 ; 317 ( 7153 ): 235 – 40 . 4 Finfer S et al . A comparison of albumin and saline for fluid resuscitation in the intensive care unit . N Engl J Med 2004 ; 350 ( 22 ): 2247 – 56 . 5 Vincent JL , Navickis RJ , Wilkes MM . Morbidity in hospitalized patients receiving human albumin : a meta-analysis of randomized , controlled trials . Crit Care Med 2004 ; 32 ( 10 ): 2029 – 38 . 6 He XM , Carter DC . Atomic structure and chemistry of human serum albumin . Nature 1992 ; 358 ( 6383 ): 209 – 15 . 7 Garcia-Martinez R et al . Albumin : pathophysiologic basis of its role in the treatment of cirrhosis and its complications . Hepatology 2013 ; 58 ( 5 ): 1836 – 46 . 8 Fanali G et al . Human serum albumin : from bench to bedside . Mol Aspects Med 2012 ; 33 ( 3 ): 209 – 90 .
李献平 , 于伟燕 , 赵彩彦 , 人血 白蛋白治疗终末期肝病研究进展 , 实用肝脏病杂志 2017 ; 20 ( 1 ): 115 – 19 . 9 Caraceni P et al . AISF-SIMTI position paper : the appropriate use of albumin in patients with liver cirrhosis . Blood Transfus 2016 ; 14 ( 1 ): 8 – 22 . 安友仲 , 合理应用人血白蛋 白 ⸺ 正确认识生理物质在病理 过程中的作用 [ J ], 中国临床营养 杂志 2008 ;( 1 ): 1 – 4 . 10 Arroyo V , García-Martinez R , Salvatella X . Human serum albumin , systemic inflammation , and cirrhosis . J Hepatol 2014 ; 61 ( 2 ): 396 – 407 . 11 Domenicali M et al . Posttranscriptional changes of serum albumin : clinical and prognostic significance in hospitalized patients with cirrhosis . Hepatology 2014 ; 60 ( 6 ): 1851 – 60 . 12 Moreau R et al . Acute-onchronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis . Gastroenterology 2013 ; 144 ( 7 ): 1426 – 37 . 13 Arroyo V . Review article : albumin in the treatment of liver diseases – new features of a classical treatment . Aliment Pharmacol Ther 2002 ; 16 ( Suppl .): S1 – S5 . 14 Runyon BA . Management of adult patients with ascites due to cirrhosis : an update . Hepatology 2009 ; 49 ( 6 ): 2087 – 107 . 15 European Association for the
Study of the Liver . EASL Clinical Practice Guidelines on the management of decompensated cirrhosis . J Hepatol 2018 ; 69 : 408 – 60 . 中华医学会肝病学分会 , 肝硬 化腹水及相关并发症的诊疗指南 , 中华肝脏病杂志 2017 ; 25 ( 9 ): 664 – 7 . 16 Vermeulen LC et al . A paradigm for consensus . The University Hospital Consortium guidelines for the use of albumin , nonprotein colloid , and crystalloid solutions . Arch Intern Med 1995 ; 155 ( 4 ): 373 – 9 . 17 Runyon BA . Introduction to the revised American Association for the Study of Liver Diseases practice guideline management of adult patients with ascites due to cirrhosis 2012 . Hepatology 2013 ; 57 ( 4 ): 1651 – 3 . 18 陈丽 , 人血白蛋白在肝硬化腹 水患者中的系统评价 , 湖南 : 湖南 师范大学 2014 . 19 Moreau R et al . Comparison of outcome in patients with cirrhosis and ascites following treatment with albumin or a synthetic colloid : a randomised controlled pilot trial . Liver Int 2006 ; 26 ( 1 ): 46 – 54 . 20 Caraceni P et al . Long-term albumin administration in decompensated cirrhosis ( ANSWER ): an open-label randomised trial . Lancet 2018 ; 391 ( 10138 ): 2417 – 29 . 21 Chen TA et al . Effect of intravenous albumin on endotoxin removal , cytokines , and nitric oxide production in
patients with cirrhosis and spontaneous bacterial peritonitis . Scand J Gastroenterol 2009 ; 44 ( 5 ): 619 – 25 . 22 Fernández J et al . A randomized unblinded pilot study comparing albumin versus hydroxyethyl starch in spontaneous bacterial peritonitis . Hepatology 2005 ; 42 ( 3 ): 627 – 34 . 23 Salerno F , Navickis RJ , Wilkes M . Albumin infusion improves outcomes of patients with spontaneous bacterial peritonitis : a meta-analysis of randomized trials . Clin Gastroenterol Hepatol 2013 ; 11 ( 2 ): 123 – 30 . 24 de Araujo A et al . Low-dose albumin in the treatment of spontaneous bacterial peritonitis : should we change the standard treatment . Gut 2012 ; 61 ( 9 ): 1371 – 2 . 25 Sigal SH et al . Restricted use of albumin for spontaneous bacterial peritonitis . Gut 2007 ; 56 ( 4 ): 597 – 9 . 26 Bernardi M , Ricci CS , Zaccherini G . Role of human albumin in the management of complications of liver cirrhosis . J Clin Exp Hepatol 2014 ; 4 ( 4 ): 302 – 11 . 27 Ginès P et al . Randomized comparative study of therapeutic paracentesis with and without intravenous albumin in cirrhosis . Gastroenterology 1988 ; 94 ( 6 ): 1493 – 502 . 28 Bernardi M et al . Albumin infusion in patients undergoing large-volume paracentesis : a meta-analysis of randomized
trials . Hepatology 2012 ; 55 ( 4 ): 1172 – 81 . 29 Alessandria C et al . Prevention of paracentesisinduced circulatory dysfunction in cirrhosis : standard vs half albumin doses . A prospective , randomized , unblinded pilot study . Dig Liver Dis 2011 ; 43 ( 11 ): 881 – 6 . 30 Martín-Llahí M et al . Terlipressin and albumin vs albumin in patients with cirrhosis and hepatorenal syndrome : a randomized study . Gastroenterology 2008 ; 134 ( 5 ): 1352 – 9 . 31 Sanyal AJ et al . A randomized , prospective , double-blind , placebo-controlled trial of terlipressin for type 1 hepatorenal syndrome . Gastroenterology 2008 ; 134 ( 5 ): 1360 – 8 . 32 Salerno F et al . Diagnosis , treatment and survival of patients with hepatorenal syndrome : a survey on daily medical practice . J Hepatol 2011 ; 55 ( 6 ): 1241 – 8 . 33 Rodríguez E et al . Terlipressin and albumin for type-1 hepatorenal syndrome associated with sepsis . J Hepatol 2014 ; 60 ( 5 ): 955 – 61 . 34 Gluud LL et al . Terlipressin for hepatorenal syndrome . Cochrane Database Syst Rev 2012 ; 9:5162 . 35 Salerno F , Navickis RJ , Wilkes MM . Albumin treatment regimen for type 1 hepatorenal syndrome : a dose-response meta-analysis . BMC Gastroenterol 2015 ; 15:167 .
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