HPE Alpha 1 Antitrypsin Deficiency | Page 2

CONTENTS INTRODUCTION 3 Alpha 1 Antitrypsin Deficiency: A special type of COPD Kenneth Chapman BIOCHEMISTRY 6 Biochemical properties of Alpha 1 Antitrypsin Oliver McElvaney and Noel McElvaney EPIDEMIOLOGY 10 Searching for a needle in a haystack Stefania Ottaviani, Angelo Corsico and Ilaria Ferrarotti 13 QUALITY OF LIFE Impact of AATD on daily activities and quality of life Robert Sandhaus TREATMENT 16 Evidence for AATD treatment Joanna Chorostowska-Wynimko and Pawel Kuca Content Director, Secondary Care Andrea Porter Art Director James Depree Group Sales Director Edward Burkle Cover image Science Photo Library