Hawkesbury Independent IND 162 November 2023 | Page 24

HEALTH & WELLBEING

Could eating germinated barley help

ulcerative colitis patients ? with Andreas Klein

Butyrate is a small fatty acid and main food for cells lining the colon . When healthy these cells provide a strong protective lining for the colon . Without butyrate colon cells slowly die , which leaves this leaves areas of colon without protection and the tissue underneath directly exposed to faeces . Areas of colon without this protective lining constitute the “ ulcers ” in ulcerative colitis .
Butyrate is normally made by bacteria that live in the colon . Indigestible fibre

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Call Andreas 0418 166 269 from the vegetables and grains we eat passes through the digestive tract into the colon , where colonic bacteria work in teams , using the fibre to make butyrate .

Many UC sufferers have abnormally low levels of butyrate in their stool . Researchers asked whether butyrate production by colonic bacteria could be increased by feeding patients appropriate fibre-containing foods .
In a 4-week open-label study , scientists gave patients suffering active UC , 30g / day of a high fibre-food supplement called Germinated barley ( GB ), a side product of beer production . Patients were kept on standard UC anti-inflammatory medications . The rationale behind the experiment was that :
1 . Fibre from germinated barley once in the colon could be efficiently utilised by Bifido and Lactobacilli bacteria to produce lactic acid and acetate ( vinegar ),
2 . These compounds would then be taken up by other gut bacteria to make the bowel-health-promoting butyrate in a process called cross-feeding .
Scientists found that after four weeks on germinated barley , patients had greater concentrations of butyrate in their stool , were clinically better , and endoscopic examination showed patients bowel walls looked significantly better . No patients had any negative side effects .
The same scientists then did a controlled study in which eighteen patients with mildly to moderately active UC , for four weeks were given either :
1 . Baseline anti-inflammatory therapy ( 7 patients ) or
2 . 20 – 30 g GBF daily , together with the baseline treatment
Patients receiving germinated barley showed :
1 . Significant clinical improvement
2 . No side effects
And a representative patient on GB underwent :
1 . Microbial stool analysis - showing increased concentrations of : a . Bifidobacterium ( acetate producing bacterium ) and b . Eubacterium limosum ( butyrate producing bacterium ). 2 . Colonoscopy showing significant improvement in bowel appearance .
Authors concluded oral therapy with germinated barley could be an effective adjunct therapy to reduce clinical signs and symptoms in UC patients .
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