Brandon Wee Siang Phon( Award Conferred 5 February 2025)
Title of Thesis:‘ Concomitant Treatment of Tocotrienol Rich Fractions and Temozolomide in Glioblastoma Spheroids Palms a Significant Synergistic Potential.’
Glioblastoma is a brain tumour that is infamous for being a thorn in the side of clinicians, with current treatment avenues barely improving patients ' survival. This thesis looked into the potential of utilising vitamin E analogues to supplement the effects of the standard chemotherapeutic drug- temozolomide. It firmly establishes the potential of vitamin E analogues as a suitable supplement to temozolomide as a future clinical option that will not break the bank for glioblastoma patients.
Supervisor: Dr Muhamad Noor Alfarizal Kamarudin Associate Supervisor: Dr B Saatheeyavaane Bhuvanendran Pillai Associate Supervisor: Professor Ammu Kutty Radhakrishnan
Timothy Yu Yee Ong( Award Conferred 5 March 2025)
Title of Thesis:‘ Role of habenula in obesity-associated aversive learning impairment.’
Obesity is a major public health issue globally that is often complicated by cognitive impairment, including fear learning. This study focused on a brain structure called the habenula in the context of high fat diet induced obesity, which is the fear learning center in zebrafish and human alike. This study aimed to address the molecular mechanism of the change of fear learning in using zebrafish model. Our main finding is that gpr151 that was primarily expressed in zebrafish dorsal habenula was downregulated and our in vivo imaging indicated a change in neural firing pattern in the diminished expression of gpr151.
Supervisor: Associate Professor Satoshi Ogawa Associate Supervisor: Professor Ishwar Parhar Associate Supervisor: Associate Professor Priyia Pusparajah
70 G R A D U A T I O N CEREMONY