Global Health Asia-Pacific Issue 2 | 2023 | Page 18


New Modern Medicine using Stem Cells for Osteoarthritis

IntellihealthPlus Clinic

Osteoarthritis ( OA ) is a common joint disorder that affects millions of people worldwide . According to the World Health Organi�ation ( WHO ), OA is the most common joint disorder globally , affecting around 10 % of men and 1� % of women over the age of 60 . It is estimated that around 302 million people worldwide have OA . While OA can affect people of all ages , it is more common in older adults . The prevalence of OA increases with age , with the highest rates observed in those over the age of 65 .

Osteoarthritis ( OA ) is a degenerative joint disease characteri�ed by the breakdown of cartilage in joints , leading to pain , stiffness , and limited mobility . Although there are various treatment options available , including surgical , non-pharmacological and pharmacological interventions , there is currently no cure for OA . However , recent advances in regenerative medicine have shown that umbilical cord mesenchymal stem cells ( �C-MSCs ) have potent therapeutic actions for treating OA .
Research into Stem cell therapy for osteoarthritis has been studied for a number of decades , which lead to the first clinical trials investigating the safety and efficacy of MSCs for OA being initiated in the early 2010s .
One of the earliest studies published in the Journal of Translational Medicine evaluated the safety and efficacy of intra-articular injection of �C-MSCs in patients with knee OA . The study found that �C-MSCs improved pain , stiffness , and function in the treated knee . Additionally , the study observed no adverse effects related to �C-MSC treatment .
This has led to hundreds of completed clinical trials using MSCs for OA around the world , and currently over 1 million stem cell transplants have been performed
worldwide for a range of conditions .
�mbilical Cord Mesenchymal stem cells ( �C-MSCs ) have been shown to have several mechanisms of action that can help alleviate the symptoms of osteoarthritis ( OA ). Here are some ways in which �C-MSCs can help with OA�
Anti�in�ammatory effects� �C-MSCs have anti-inflammatory properties that can help reduce inflammation in the affected joint . OA is characteri�ed by chronic inflammation , which can cause pain and further damage to the joint . �C-MSCs can help reduce inflammation by suppressing the activity of immune cells that produce inflammatory cytokines .
Adult ��ondro�enesis� �C-MSCs have the ability to stimulate chondrogenesis , which leads to cartilage and extracellular matrix formation . Cartilage is essential for healthy joint function , and OA is characteri�ed by the breakdown and loss of cartilage ..
Paracrine effects� �C-MSCs secrete a variety of growth factors and cytokines that can stimulate tissue repair and regeneration . These growth factors can promote the growth of new blood vessels , stimulate the growth of new tissue , and reduce inflammation in the affected joint .
�mmunosuppressive effects� �C-MSCs have the ability to modulate the immune system , which can help reduce the inflammatory response in the affected joint . By suppressing the activity of immune cells , �C-MSCs can help prevent further damage to the joint and promote tissue repair .
Overall , the therapeutic effects of �C-MSCs in OA are due to their ability to promote tissue regeneration , reduce inflammation , and modulate the immune system .
16 ISSUE 2 | 2023 GlobalHealthAsiaPacific . com