AI is also gaining currency as an alternative to the standard approach to detecting embryo abnormalities , PGT-A . Can you compare the two approaches ? Tee Sze Tian : In PGT-A , we have to take some cells from the embryo and subject them to genetic testing . This makes it the most accurate method to identify genetic abnormalities , claiming close to 99 percent accuracy rates , because it tests embryos directly . However , it ’ s highly skill dependent and any minimal error in the procedure can compromise the embryo ’ s viability , increasing the risk of a failed pregnancy .
By contrast , AI is a non-invasive approach that selects embryos whose shapes are more likely to be genetically normal and lead to a pregnancy . We hope the technology will become a better alternative to PGTA , making genetic testing less harmful for embryos and equally , if not more , accurate . The genetic assessment algorithm is still in the research phase , and we need solid evidence to prove its accuracy and benefit before we make it a feasible therapy option for patients .
Even if AI provides 100 percent accuracy in identifying genetically normal embryos , it will remain an embryo selection tool . It will not rectify embryo abnormalities or eliminate the risk of producing abnormal embryos , which increases with age and medical history , resulting in genetic complications . So , advancements in AI should not perpetuate the culture of wanting to have a child later in life or continuing an unhealthy lifestyle that can disrupt your fertility health .
Beyond advances in genetic screening , what ’ s the promise of AI in the near future ? Tee Sze Tian : Another aspect AI could also make a difference by offering a more accurate and personalised treatment . Despite constant improvement in fertility treatment regime and
GlobalHealthAsiaPacific . com ISSUE 1 | 2023
55