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either injected daily with leptin or a placebo (i.e. bogus alternative). At the end of
the 24-week period, the leptin group lost significantly more weight than the
placebo and a higher percentage of fat vs. muscle.
In 2002, Rosenbaum et al. administered low-dose leptin to subjects (male and
female) who had dieted to a 10% decrease in body weight. During the diet
period, thyroid hormone levels, 24-hr energy expenditure, and other metabolic
markers substantially decreased. The result of the leptin replacement therapy?
“All of these endocrine changes were reversed…”
Thyroid output and daily calorie burn increased back to pre-diet levels.
In 2003, Fogteloo et al. showed that leptin injections “tended to reduce the
decline of energy expenditure associated with energy restriction, whereas the
tendency of energy intake to increase back to baseline levels in placebo-treated
subjects was largely prevented in subjects treated with leptin.”
Yeah, that’s a mouthful. Let me put in simple terms: not only did the leptin group
experience less of a decline in metabolism, but they were also less hungry,
allowing them to more easily stick to the prescribed diet.
In 2004, Welt et al. reported that leptin given to a group of women with thyroid
disorder immediately raised circulating concentrations of the thyroid hormones
T3 and T4.
In 2005, Rosenbaum and company were at it again, once again showing that
energy expenditure and circulating concentrations of T3 and T4 all returned to
pre-weight-loss levels with regular leptin injections.
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