Get Acne No More Review PDF eBook Book Free Download | Page 24

1BChapter 2—The Truth About Acne
27
Acne and The Immediate Causes
Acne is usually described as an inflammatory skin disease. The inflammatory
response is influenced by many “on-the-surface” factors such as the over-
production of sebum (oil) and keratin by the sebaceous glands. This over-
production of oil clogs the hair follicle and leads to bacterial growth. The bacteria
multiplies and causes inflammation, and the result can appear in the form of what
is known as a blackhead (an open comedo) or a whitehead (if it's below the
surface).
The Immediate Causes of Acne
Basically, the process of acne formation can be divided into 4 major external
causes:
1)Blockage of the pore
This occurs when the epithelial cells lining the pore mature and die. The epithelial
cells turn from keratinocytes to corneocytes and become flatter and tougher.
These scaly, rough corneocytes block the pore.
2)Too much skin oil (sebum)
This is caused when there is a large presence of male hormones that circulate in
the blood stream. These hormones trigger the oil glands to produce excessive
amounts of sebum.
3)Bacterial colonization
Clogged pores, extra amounts of sebum and certain blood toxins create the
perfect environment for acne bacteria to multiply and thrive inside the
microcomedo.
4)Infection and inflammation of the comedo and surrounding tissue.
Certain substances found within the cell walls, where the bacteria multiply,
stimulate the immune system to produce localized pro-inflammatory hormones
2003 - 201 2 A c ne N o M or e- M ik e W a l d en -
Page 27