The team observed increased levels of proteins called ' myokines ' which are produced by skeletal muscles and can suppress tumour growth and even help actively fight cancerous cells by stimulating a range of anti-cancer processes in the body . The new EMRI study has shown a single bout of exercise can elevate myokines even further and induce additional cancer suppression .
This exercise induced medicine occurs in patients with incurable , advanced cancer where the disease has well and truly taken hold and patients have already received extensive treatment over many years . Nine patients with late-stage prostate cancer performed 34 minutes of high intensity exercise on a stationary cycle , with blood serum collected immediately before and after , and then again 30 minutes post-workout . The serum obtained immediately after this " dose " of exercise contained elevated levels of anti-cancer myokines resulting in suppressed growth of prostate cancer cells in vitro by around 17 percent . Serum myokine levels and cancer suppression returned to baseline after 30 minutes .
EMRI researcher and study supervisor Professor Rob Newton said it was a breakthrough moment in exercise oncology . " The findings from our work are particularly exciting because we report for the first time ever that men with advanced prostate cancer are able to produce an acute elevation in anti-cancer molecules called myokines in response to a single bout of vigorous exercise ," he said . " This is helping us to understand why patients with cancer who exercise exhibit slower disease progression and survive for longer ." " The optimal dose of exercise is not yet known , but it is likely to be 20-plus minutes each day and must include resistance training to grow the muscles , increase the size and capacity of the internal pharmacy , and stimulate the myokine production ," he said . The study results were recentlys published in Prostate Cancer and Prostatic Diseases .
SYMPTOMS OF ' LONG COVID ' IN CHILDREN CHANGE OVER TIME
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NEW SYMPTOMS MAY APPEAR IN CHILDREN UP to a year after initial infection with Covid-19 , finds a new study led by UCL researchers . The Children and young people with Long Covid ( CLoCk ) study , published in The Lancet Regional Health — Europe , is the world ' s largest study on long Covid in children .
Researchers asked children aged 11 to 17 about their health six months and 12 months after taking a PCR test between September 2020 and March 2021 . They also asked them to recall their symptoms at the time of taking the test . None of the children initially invited to participate in the study had been hospitalized . In total the researchers examined data from 5,086 children , 2,909 of whom tested positive for Covid-19 , and 2,177 of whom tested negative . Researchers asked the children and young people what they had experienced from a list of 21 symptoms , including shortness of breath and tiredness , as well as using validated scales to assess quality of life , mental health , wellbeing and fatigue .
The team found that , at time of testing , health issues were more common in children and young people who had tested positive for the virus compared to those who tested negative , as well as six months and 12 months post PCR test . For example , among the test-positives , 10.9 % reported fatigue at all three time points while among test-negatives only 1.2 % reported fatigue at all three time points .
They also noted that the symptoms experienced changed over the course of a year . And while some of the children ' s original symptoms declined , new symptoms were reported .
This was also the case when researchers looked at scales measuring poor quality of life , experiencing emotional and behavioral difficulties , poor wellbeing and fatigue .
As a result , the researchers have found that the symptoms of long Covid experienced by children and young people change over time and that clinicians should be aware of this . #
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