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even more sensitive initiating cell death under both Beethoven , Ligeti and Mozart compared to controls ( p < 0.05 ). The authors concluded that cell changes may not only be due to the kind of music exposure but also particular cell characteristics . |
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Cell proliferation and decrease in cells
United States scientists exposed several strains of oral mucosa cells to a less sophisticated “ musical ” test , i . e ., the sounds of an electric toothbrush . ⁸ The cell cultures were exposed to he acoustic energy of a toothbrush twice a day in the laboratory for 0 , 15 , 30 , 60 or 120 seconds over ten days at 261Hz with 87 dB ( volume of a saxophone playing ). Mucosa cells reacted differently depending on the duration of exposure . While sound exposure
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for more than two times 30 seconds / day increased the cells by 25.5 percent , two times 120 seconds / day of sound exposure resulted in a 30.9 percent decrease in cell number ( p < 0.001 ). Authors concluded that sound energy modifies the behavior of cells in culture . Conversely , collagen production by fibroblasts remained unimpacted by the exposure to sound and stayed at the same level in all groups .
Bone augmentation by nanovibrations
Sound waves are mechanical vibrations which continue through the air as variations in pressure and density . Scottish scientists have been investigating the question of how vibrations affect the growth of stem cells . Not only chemical substances but also mechanical
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Percentage of dead cells
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stimuli can induce stem cells to differentiate into different cell types , such as bone , cartilage , ligaments or muscles . Adam Curtis , Professor for Cell Energy at the University of Glasgow realized that cells “ creep around ” on surfaces . How would such cells behave if they were subjected to minor vibrations on these surfaces ? In fact , natural bodily processes , such as walking , breathing or kissing , also generate “ nanovibrations ” with a frequency range of around 970 Hz . Using a self-developed bioreactor , the Scottish researchers were able to show that irrespective of other external factors , mesenchymal stem cells differentiate into mineralized three-dimensional tissue when impacted by so-called nanokicking resonating at around 1 kHz . ⁹ “ Bone marrow-derived stem cells converted into osteoblasts on a large scale in our experiments , and without the use of chemical cocktails or highly complicated technology ,” explained Matt Dalby of the Centre for Cell Engineering at the University of Glasgow .¹ ⁰ Apart from continuing the “ bone work ,” the team is now planning cooperations with rehabilitation specialists in order to help patients with bone marrow injuries . |