Frontier Pharma Alzheimer’s Disease and Associated Indications Frontier Pharma Alzheimer’s Disease and Associated | Page 5

4.7.1 Pharmacological Intervention 21
4.7.2 Non-pharmacological Intervention 22
4.8 Overview of Marketed Products 23
4.9 Indications Associated with Alzheimer’s Disease 26
4.9.1 Anxiety 26
4.9.2 Depression 27
4.9.3 Psychosis 28
4.9.4 Insomnia 29
5 Assessment of Pipeline Product Innovation 30
5.1 Overview 30
5.2 Pipeline by Stage of Development and Molecule Type 30
5.2.1 Alzheimer’s Disease 30
5.2.2 Alzheimer’s-Disease-Associated Indications 31
5.3 Pipeline by Molecular Target 33
5.3.1 Alzheimer’s Disease 33
5.3.2 Alzheimer’s-Disease-Associated Indications 35
5.4 Comparative Distribution of Programs between the Market and Pipeline by Molecular Target
Class 36
5.4.1 Alzheimer’s Disease 36
5.4.2 Alzheimer’s-Disease-Associated Indications 37
5.5 First-in-Class Programs Targeting Novel Molecular Targets 37
5.5.1 Alzheimer’s Disease 37
5.5.2 Alzheimer’s-Disease-Associated Indications 41
5.6 Ratio of First-in-Class Products to First-in-Class Targets 44
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