Forum for Nordic Dermato-Venereology Nr 3, 2018 | Page 25

Jussi Leppävirta – Epidemiology of neurofibromatosis type 1 in Finland: incidence, mortality, pregnancies and congenital malformations
• Cesarean section, hypertension during pregnancy/preec-
lampsia, oligohydramnios, placental abruption, poor fetal
growth and maternal care for disproportion were signifi-
cantly more common among mothers with NF1 than in
controls. (II)
• NF1 of the mother decreases birth weight, while NF1 of the
fetus increases it. Head circumference at birth is increased
by NF1 of the fetus but is not significantly affected by NF1
of the mother. (III)
• The frequency of congenital malformations is increased
among NF1 children. Congenital malformations are in-
creased in cardiovascular, musculoskeletal and urinary
systems. Also risk for malformations in the group of eye,
ear, head and neck was increased. (IV)
Forum for Nord Derm Ven 2018, Vol. 23, No. 3
List of original publications
1. Uusitalo E, Leppävirta J, Koffert A, Suominen S, Vahtera J, Vahl-
berg T, et al. Incidence and mortality of neurofibromatosis: a total
population study in Finland. J Invest Dermatol 2015; 135: 904.
2. Leppävirta J, Kallionpää RA, Uusitalo E, Vahlberg T, Pöyhönen M,
Timonen S, et al. The pregnancy in neurofibromatosis 1: A retro-
spective register-based total population study. A J Med Genetics
Part A, 2017, 173(10), 2641- 2648.
3. Leppävirta J, Kallionpää RA, Uusitalo E, Vahlberg T, Pöyhönen
M, Peltonen J, Peltonen S. Neurofibromatosis type 1 of the child
increases birth weight. (submitted manuscript)
4. Leppävirta J, Kallionpää RA, Uusitalo E, Vahlberg T, Pöyhönen M,
Peltonen J, Peltonen S. Congenital anomalies in neurofibromatosis
1: a retrospective register-based total population study. Orphanet
J Rare Dis 2018; 13(5).
D issertation
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