Anders Vahlquist – Excerpta from Volume 96 of ActaDV
Fig . 2 . Interleukin ( IL ) 36γ expression in different erythroderma subsets . ( a ) Number of IL-36γ-positive cell layers detected by immunohistochemistry in the different disease subsets ( mean expression ± standard error of the mean ( SEM )). ( b ) Number of specimens with low ( 0 – 1 cell layers ), fair ( 2 – 3 cell layers ) and strong ( ≥ 4 cell layers ) expression of IL-36γ within the different subsets . ( c – f ) Representative IL-36γ-micrographs ( eczema , psoriasis ( Pso ), drug-reaction and cutaneous T-cell lymphoma ( CTCL ), original magnifica tion × 200 , respectively ). ( From ref 10 with permission from Acta Derm Venereol ).
one of the founding members of EADV . A few titles from this supplement illustrate its almost textbook-like content : “ From evidence-based medicine to human-based medicine in psychosomatics ” ( 11 ), “ Psychodermatology in clinical practice ” ( 12 ), and “ Delusional infestations : State of the Art ” ( 13 ).
Various psychological aspects of psoriasis , including the efficacy of biofeedback and cognitive-behavioural therapy , are also covered in this supplement , as well as in some original reports in the regular issues of ActaDV . One example is a recent Danish study about the association between psoriasis and new-onset
ISSN 0001-5555
Volume 96 2016
Supplement 217
A Non-profit International Journal for Interdisciplinary Skin Research , Clinical and Experimental Dermatology and Sexually Transmitted Diseases
Official Journal of - The International Forum for the Study of Itch - European Society for Dermatology and Psychiatry
FRONTIERS IN PSYCHO CUTANEOUS DISEASES
SELECTED WRITINGS IN PSYCHOSOMATICS , PSYCHO- DERMATOLOGY AND PSYCHO-NEURO-ENDOCRINE- IMMUNOLOGY
A MEMORIAL PUBLICATION FOR EMILIANO PANCONESI
Authors : Lucía Tomas-Aragones Uwe Gieler M . Dennis Linder
Acta Dermato-Venereologica
www . medicaljournals . se / adv
Fig . 3 . Front cover of Supplement 217 , 2016 . depression ( 14 ). One important finding in this study is that severe psoriasis especially in younger individuals may itself be a risk factor for new-onset depression .
Rosacea
In a review article by Professor Bodo Melnik , Germany ( 15 ), novel aspects about the pathogenesis of rosacea are covered ; a major conclusion is that the Celtic genetic heritage in the European population might be blessed for increasing our life expectance , but at the same time can be blamed for the high incidence rosacea , especially in the Nordic countries . The Januslike effects of cathelicidin antimicrobial peptide ( CAMP ) are highlighted ; on the one hand protecting against mycobacteria and on the other hand causing a readiness to intense skin inflammation . The theory goes like this : The expression of CAMP is upregulated by vitamin D-dependent ( VDR ) and independent ( C / EBP ) transcription factors , the former of which will be insufficient during UV-deficient conditions ( Fig . 4 ). Celts however appear evolutionary to have overcome the geographical disadvantage of deficient CAMP production during wintertime via activation of the alternative , C / EBP pathway , thus retaining a good protection against mycobacteria . However , C / EBP is also a transcription factor of Toll-like receptor ( TLR ) -mediated innate immune reactions and cellular stress responses , which may explain the reduced threshold for skin stressor in patients with rosacea and a Celtic ancestry .
These ideas about rosacea pathogenesis , also presented in many other journals , will no doubt initiate a search for new
Forum for Nord Derm Ven 2016 , Vol . 21 , No . 4 Info from the Editor of ActaDV 91