Anders Vahlquist – Excerpta from Volume 96 of ActaDV
Fig. 2. Interleukin( IL) 36γ expression in different erythroderma subsets.( a) Number of IL-36γ-positive cell layers detected by immunohistochemistry in the different disease subsets( mean expression ± standard error of the mean( SEM)).( b) Number of specimens with low( 0 – 1 cell layers), fair( 2 – 3 cell layers) and strong( ≥ 4 cell layers) expression of IL-36γ within the different subsets.( c – f) Representative IL-36γ-micrographs( eczema, psoriasis( Pso), drug-reaction and cutaneous T-cell lymphoma( CTCL), original magnifica tion × 200, respectively).( From ref 10 with permission from Acta Derm Venereol).
one of the founding members of EADV. A few titles from this supplement illustrate its almost textbook-like content:“ From evidence-based medicine to human-based medicine in psychosomatics”( 11),“ Psychodermatology in clinical practice”( 12), and“ Delusional infestations: State of the Art”( 13).
Various psychological aspects of psoriasis, including the efficacy of biofeedback and cognitive-behavioural therapy, are also covered in this supplement, as well as in some original reports in the regular issues of ActaDV. One example is a recent Danish study about the association between psoriasis and new-onset
ISSN 0001-5555
Volume 96 2016
Supplement 217
A Non-profit International Journal for Interdisciplinary Skin Research, Clinical and Experimental Dermatology and Sexually Transmitted Diseases
Official Journal of- The International Forum for the Study of Itch- European Society for Dermatology and Psychiatry
FRONTIERS IN PSYCHO CUTANEOUS DISEASES
SELECTED WRITINGS IN PSYCHOSOMATICS, PSYCHO- DERMATOLOGY AND PSYCHO-NEURO-ENDOCRINE- IMMUNOLOGY
A MEMORIAL PUBLICATION FOR EMILIANO PANCONESI
Authors: Lucía Tomas-Aragones Uwe Gieler M. Dennis Linder
Acta Dermato-Venereologica
www. medicaljournals. se / adv
Fig. 3. Front cover of Supplement 217, 2016. depression( 14). One important finding in this study is that severe psoriasis especially in younger individuals may itself be a risk factor for new-onset depression.
Rosacea
In a review article by Professor Bodo Melnik, Germany( 15), novel aspects about the pathogenesis of rosacea are covered; a major conclusion is that the Celtic genetic heritage in the European population might be blessed for increasing our life expectance, but at the same time can be blamed for the high incidence rosacea, especially in the Nordic countries. The Januslike effects of cathelicidin antimicrobial peptide( CAMP) are highlighted; on the one hand protecting against mycobacteria and on the other hand causing a readiness to intense skin inflammation. The theory goes like this: The expression of CAMP is upregulated by vitamin D-dependent( VDR) and independent( C / EBP) transcription factors, the former of which will be insufficient during UV-deficient conditions( Fig. 4). Celts however appear evolutionary to have overcome the geographical disadvantage of deficient CAMP production during wintertime via activation of the alternative, C / EBP pathway, thus retaining a good protection against mycobacteria. However, C / EBP is also a transcription factor of Toll-like receptor( TLR)-mediated innate immune reactions and cellular stress responses, which may explain the reduced threshold for skin stressor in patients with rosacea and a Celtic ancestry.
These ideas about rosacea pathogenesis, also presented in many other journals, will no doubt initiate a search for new
Forum for Nord Derm Ven 2016, Vol. 21, No. 4 Info from the Editor of ActaDV 91