Information from the Editor of ActaDV
Excerpta from Volume 96 of ActaDV
Anders Vahlquist , Editor-in-Chief of Acta Dermato-Venereologica
Department of Dermato-Venereology , Uppsala University Hospital , Uppsala , Sweden . E-mail : anders . vahlquist @ medsci . uu . se
In an attempt to illustrate the width and novelty of clinical and experimental research presented in Acta Dermato Venereologica , the Editor-in-Chief Anders Vahlquist has selected 20 out of nearly 250 publications in 2016 . Here , a short commentary on each of the papers from 5 different research areas is presented ( in alphabetical order ).
Cancer
The first paper in volume 96 of ActaDV is a review by Professor Irene Leigh and her co-workers in London and Dundee ( 1 ), describing the promise of genomics in dissecting various disease mechanisms in squamous cell carcinoma ( SCC ), with the ultimate goal of finding new treatment targets ( Fig . 1 ). Among the many possible therapies , inhibitors of various epidermal growth factors and immunomodulatory drugs are discussed in some depth .
In another report , Professor Nicole Basset-Seguin and her team in Paris present the results of photodynamic therapy ( PDT ) in
105 cases of Bowen ’ s disease , focusing on the relapse rates of invasive cancers ( 2 ). SCC occurred post-PDT in 16 out of the treated fields , but whether or not these “ treatment failures ” originated from microscopic nests of pre-existing SCC within the Bowenoid lesions before PDT is not known . However , the results remind us about the importance of careful follow-ups of PDT-treated Bowen ’ s disease , especially in immunosuppressed individuals .
Immunosuppression is also a factor of importance in the context of basal cell carcinoma ( BCC ). In a Danish study , Omland et al . examine the role of regulatory T cells ( T-regs )
Fig . 1 . Summary of aetiology factors in cutaneous squamous cell carcinoma ( SCC ). AK : actinic keratosis . ( From ref 1 with permission from Acta Derm Venereol ).
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