Mehdi Farshchian – Roles of Novel Biomarkers in Progression of Cutaneous Squamous Cell Carcinoma
indicates the role of innate immunity and inflammation in the progression of cSCC .
In conclusion , the findings of the thesis project revealed novel biomarkers for the progression of cSCC . SerpinA1 level can be used as a simple way to diagnose cSCC in early stages . The findings on the role of EphB2 and AIM2 in the progression of cSCC identified them as attractive therapeutic targets for cSCC . This may open new horizons for the treatment of cSCC , especially metastatic and unresectable tumours . AIM2 , in particular , could be a novel therapeutic target for cSCC in immunosuppressed patients .
List of original publications
I . Farshchian M , Kivisaari A , Ala-aho R , Riihilä P , Kallajoki M , Grénman R , et al . Serpin peptidase inhibitor clade A member 1 ( SerpinA1 ) is a novel biomarker for progression of cutaneous squamous cell carcinoma . Am J Pathol 2011 ; 179 : 1110 – 1119 .
II . Farshchian M , Nissinen L , Siljamäki E , Riihilä P , Toriseva M , Kivisaari A , et al . EphB2 promotes progression of cutaneous squamous cell carcinoma . J Invest Dermatol 2015 ; 135 : 1882 – 1892 .
III . Farshchian M , Nissinen L , Siljamäki E , Riihilä P , Toriseva M , Kivisaari A , et al . EphB2 promotes progression of cutaneous squamous cell carcinoma . J Invest Dermatol 2015 ; 135 : 1882 – 1892 .
Work-related Skin Disease in Norway
Jose Hernán Alfonso
Department of Occupational Medicine and Epidemiology , National Institute of Occupational Health , Pb 8149 Dep , NO-0033 Oslo , Norway . E-mail : jose . alfonso @ stami . no
Jose Hernán Alfonso at the National Institute of Occupational Health in Oslo , Norway , recently defended his doctoral thesis , titled “ Skin diseases in Norway and cutaneous squamous cell carcinoma in four Nordic countries : the role of occupation and occupational exposures . A population-based study ”, at the University of Oslo . Opponents were Associate Professor Åke Svensson , University of Lund , Malmø , and Professor María Albin , Karolinska Institutet , Stockholm , Sweden . The thesis book is available at : https :// www . duo . uio . no / handle / 10852 / 52852 .
Skin diseases are associated with a substantial burden in the global context of health . Work-related skin diseases , most of them preventable by reduction of occupational exposures , represent a challenge for workers world-wide .
Whilst epidemiological studies at the population level are an important tool to determine etiologic and contributing factors of work-related skin diseases , little is known about the contribution of occupational exposures to the burden of skin problems and diseases in Norway . Moreover , the variation in the relative risk of cutaneous squamous cell carcinoma between occupational categories of the Nordic countries has not yet been assessed .
In his doctoral thesis , Jose Hernán Alfonso addresses the role and importance of occupation and occupational exposures in the occurrence and burden of skin problems and diseases in
Fig . 1 . Maria Albin ( 2 nd opponent ), Jose Hernán Alfonso , Anne Olaug Olsen ( 3 rd member of the evaluating committee ) and Petter Gjersvik ( acting dean ).
Forum for Nord Derm Ven 2016 , Vol . 21 , No . 4 Dissertations 95