Mehdi Farshchian – Roles of Novel Biomarkers in Progression of Cutaneous Squamous Cell Carcinoma
indicates the role of innate immunity and inflammation in the progression of cSCC.
In conclusion, the findings of the thesis project revealed novel biomarkers for the progression of cSCC. SerpinA1 level can be used as a simple way to diagnose cSCC in early stages. The findings on the role of EphB2 and AIM2 in the progression of cSCC identified them as attractive therapeutic targets for cSCC. This may open new horizons for the treatment of cSCC, especially metastatic and unresectable tumours. AIM2, in particular, could be a novel therapeutic target for cSCC in immunosuppressed patients.
List of original publications
I. Farshchian M, Kivisaari A, Ala-aho R, Riihilä P, Kallajoki M, Grénman R, et al. Serpin peptidase inhibitor clade A member 1( SerpinA1) is a novel biomarker for progression of cutaneous squamous cell carcinoma. Am J Pathol 2011; 179: 1110 – 1119.
II. Farshchian M, Nissinen L, Siljamäki E, Riihilä P, Toriseva M, Kivisaari A, et al. EphB2 promotes progression of cutaneous squamous cell carcinoma. J Invest Dermatol 2015; 135: 1882 – 1892.
III. Farshchian M, Nissinen L, Siljamäki E, Riihilä P, Toriseva M, Kivisaari A, et al. EphB2 promotes progression of cutaneous squamous cell carcinoma. J Invest Dermatol 2015; 135: 1882 – 1892.
Work-related Skin Disease in Norway
Jose Hernán Alfonso
Department of Occupational Medicine and Epidemiology, National Institute of Occupational Health, Pb 8149 Dep, NO-0033 Oslo, Norway. E-mail: jose. alfonso @ stami. no
Jose Hernán Alfonso at the National Institute of Occupational Health in Oslo, Norway, recently defended his doctoral thesis, titled“ Skin diseases in Norway and cutaneous squamous cell carcinoma in four Nordic countries: the role of occupation and occupational exposures. A population-based study”, at the University of Oslo. Opponents were Associate Professor Åke Svensson, University of Lund, Malmø, and Professor María Albin, Karolinska Institutet, Stockholm, Sweden. The thesis book is available at: https:// www. duo. uio. no / handle / 10852 / 52852.
Skin diseases are associated with a substantial burden in the global context of health. Work-related skin diseases, most of them preventable by reduction of occupational exposures, represent a challenge for workers world-wide.
Whilst epidemiological studies at the population level are an important tool to determine etiologic and contributing factors of work-related skin diseases, little is known about the contribution of occupational exposures to the burden of skin problems and diseases in Norway. Moreover, the variation in the relative risk of cutaneous squamous cell carcinoma between occupational categories of the Nordic countries has not yet been assessed.
In his doctoral thesis, Jose Hernán Alfonso addresses the role and importance of occupation and occupational exposures in the occurrence and burden of skin problems and diseases in
Fig. 1. Maria Albin( 2 nd opponent), Jose Hernán Alfonso, Anne Olaug Olsen( 3 rd member of the evaluating committee) and Petter Gjersvik( acting dean).
Forum for Nord Derm Ven 2016, Vol. 21, No. 4 Dissertations 95